ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Heart Failure and Transplantation
This article is part of the Research TopicNavigating Multimorbidity and Frailty in Geriatric Cardiovascular CareView all 3 articles
Analysis of the value of nutritional status indexes (ALB, Hb, GNRI) in prognostic assessment of elderly patients with chronic heart failure
Provisionally accepted
- Xi'an Fifth Hospital, Xi'an, China
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OBJECTIVE: This study evaluated the prognostic value of nutritional status indexes (albumin (ALB), hemoglobin (Hb), Geriatric Nutritional Risk Index (GNRI)) in elderly chronic heart failure (CHF) patients. METHODS: A total of 190 elderly CHF patients were categorized into good (n=142) and poor (n=48) prognosis groups based on 1-year outcomes (rehospitalization or all-cause death). Clinical data, including cardiac function (New York Heart Association (NYHA) class), inflammatory markers, and nutritional indexes (ALB, Hb, GNRI), were analyzed. Spearman correlation was used to assess the relationship between nutritional markers and NYHA class. Patients were stratified by median ALB, Hb, and GNRI levels to compare poor prognosis incidence. Kaplan-Meier survival and Cox regression analyses identified prognostic factors, while Receiver Operating Characteristic (ROC) curves evaluated predictive performance. RESULTS: The poor prognosis group exhibited significantly lower ALB, Hb, and GNRI levels (P < 0.001). These markers declined with worsening NYHA class (P < 0.001) and correlated negatively with cardiac function. Low ALB, Hb, and GNRI groups had higher poor prognosis rates (P < 0.001), confirmed by Kaplan-Meier analysis. Cox regression identified left ventricular ejection fraction (LVEF), N-terminal pro-B-type natriuretic peptide (NT-proBNP), NYHA class, ALB, Hb, and GNRI as independent prognostic factors. ROC analysis showed ALB (area under the curve (AUC) = 0.845), Hb (AUC = 0.884), and GNRI (AUC = 0.896) as strong predictors with high sensitivity/specificity. CONCLUSION: Reduced ALB, Hb, and GNRI levels are associated with poor CHF prognosis in elderly patients. These nutritional indexes offer reliable predictive value for clinical prognosis assessment.
Keywords: Chronic heart failure in the elderly, Cox regression analysis, Geriatric Nutritional Risk Index, Nutritional status indexes, prognosis, ROC
Received: 31 Oct 2025; Accepted: 06 Feb 2026.
Copyright: © 2026 Xue, Wang, Wang, Gao and Zhangsun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yanling Zhangsun
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