CASE REPORT article
Front. Cardiovasc. Med.
Sec. Thrombosis and Haemostasis
Thromboembolism in the Left Main Coronary Artery of a Patient With Membranous Nephropathy: A Case Report
Baoguo Wang
禄 鸣
Hongjun Zhang
Chaoqun Huang
Weihua Zhang
The First Hospital of Jilin University, Changchun, China
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Abstract
Background: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults and a well‑established risk factor for hypercoagulability. Although venous thromboembolism is frequently documented, arterial thrombosis—particularly acute thrombosis of the left main coronary artery (LMCA)—remains exceedingly rare. Case Presentation: We report a fatal case of a 48‑year‑old male with a 10‑year history of MN who presented with intermittent chest pain for 17 hours and a marked elevation in troponin levels. Emergency coronary angiography revealed extensive thrombosis in the LMCA. Despite thrombus aspiration and stent implantation, the patient developed refractory cardiogenic shock and died. Conclusion: Acute LMCA thrombosis associated with MN is a rare occurrence. This case highlights that the hypercoagulable state linked to MN is not confined to venous thromboembolic events and may, in rare instances, lead to fatal arterial thrombosis.
Summary
Keywords
acute myocardial infarction, Hypercoagulability, Left main coronary artery, Membranous nephropathy, Thrombosis
Received
18 November 2025
Accepted
09 February 2026
Copyright
© 2026 Wang, 鸣, Zhang, Huang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Weihua Zhang
Disclaimer
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