ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Lipids in Cardiovascular Disease
This article is part of the Research TopicThe role of Lipid Metabolism in Atherosclerosis: Pathways and InterventionsView all articles
From Lipid Dysbalance to Cardiorenal Decompensation: ApoB/ApoA1 Ratio Is Associated with Acute Cardiorenal Injury in CAD Patients
Provisionally accepted
- Tiantai People's Hospital of Zhejiang Province, Taizhou, China
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Background: Cardiorenal syndrome (CRS) involves cardiac dysfunction leading to renal impairment. Type I CRS (acute heart failure causing acute kidney injury) has high mortality in coronary artery disease (CAD) patients. The apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio is a cardiovascular risk marker, but its role in CRS is unclear. Objective: To assess the association between ApoB/ApoA1 ratio and Type I CRS in CAD patients. Methods: Retrospective analysis of 269 CAD patients with heart failure (2022-2024), categorized into simple heart failure and CRS groups. Multivariable logistic regression and ROC analysis evaluated the ApoB/ApoA1 ratio's predictive value. Results: CRS patients showed higher age, diabetes prevalence, triglycerides, ApoB, creatinine, and ApoB/ApoA1 ratio, but lower ApoA1. Age and ApoB/ApoA1 ratio were independent CRS risk factors. The ratio demonstrated moderate predictive accuracy (AUC = 0.782). Conclusion: The ApoB/ApoA1 ratio is independently associated with Type I CRS risk and may serve as a useful biomarker for early risk identification in CAD patients with acute heart failure.
Keywords: ApoB/ApoA1 ratio, apolipoprotein A1, Apolipoprotein B, cardiorenal syndrome, Coronary Artery Disease
Received: 26 Nov 2025; Accepted: 16 Feb 2026.
Copyright: © 2026 Pang, Wang, Zhao, Cai, Yu, Qiu and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qianying Xie
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