REVIEW article
Front. Cardiovasc. Med.
Sec. Cardiovascular Metabolism
Engineered bacteria: a novel era for metabolic,cardiovascular and cerebrovascular diseases therapy
Xiangnan Chen 1
Wu Yuzhe 1
Ruiqi Sang 1
Songyun Wang 1,2
1. Wuhan University, Wuhan, China
2. Wuhan University Renmin Hospital, Wuhan, China
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Abstract
There are a large number of people suffer from metabolic, cardiovascular, and cerebrovascular diseases, posing a significant threat to public health. Previous studies have suggested that cardiovascular and cerebrovascular diseases are frequently accompanied by changes in intestinal flora and metabolites, which play a crucial role in the progression of metabolic, cardiovascular and cerebrovascular diseases. Engineered bacteria, as a tool for efficiently expressing foreign genes within a bacterial cell line, has attracted considerable attention for cancer treatment over the past decades. In recent years, engineered bacteria has been extended to metabolic disorders, cardiovascular and cerebrovascular diseases therapy and has been a promising tool. However, several challenges persist, including the necessity of more refined strain selection and design. Furthermore, there is no relevant review on the application of engineering bacteria in the fields of metabolic diseases and cardiovascular diseases currently. Therefore, this review is aimed to explore the alterations of intestinal microbiota and metabolome associated with metabolic and cardio-cerebrovascular diseases, as well as the potential application of engineered bacteria in treating these conditions.
Summary
Keywords
cardiovascular disease, cerebrovascular disease, Engineered bacteria, Gut Microbiota, Metabolic Diseases
Received
30 November 2025
Accepted
19 February 2026
Copyright
© 2026 Chen, Yuzhe, Sang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Songyun Wang
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.