In the published article, there was an error in Table 2 as published. This was due to a formatting error during publication causing rows to become misplaced in the final printed copy and subscript information to be lost.
TABLE 2
| Experimental design | Experiment | Conditions/parallel experiments | Replicates |
|---|---|---|---|
| Characterisation of Pt/C | Oxygen adsorption | In ambient | 3 |
| Oxygen adsorption | In nitrogen | 3 | |
| BET | In nitrogen | 3 | |
| Tafel plot | In nitrogen | 3 | |
| Oxygen concentration change | In nitrogen | 3 | |
| eLOS hypoxia 6 images randomly taken with minimum 100 cells each; minimum 1,000 cells per replicate | Hypoxic response | Negative control | 3 |
| Hypoxic response | Time conditions | 3 each | |
| Hypoxic response | Positive control (DMOG 250 µM) | 3 | |
| Acute hypoxia | Negative control | 3 | |
| Acute hypoxia | Time conditions | 3 | |
| Focal hypoxia | Negative control | 3 | |
| Focal hypoxia | Position conditions | 3 | |
| Focal hypoxia | Positive control | 3 | |
| Apoptosis study | pH change | Different solutions | 3 each |
| H 2 O 2 generation | Different solutions | 3 each | |
| hNPC apoptosis | Negative control | 3 | |
| hNPC apoptosis | H2O2 concentrations | 3 each | |
| hNPC apoptosis | Positive control (Staurosporine 100Â nM) | 3 | |
| Neuron focal hypoxia | Hypoxia at microchannel device | Positional conditions | 3 |
| Cortical neuron model | Negative control | 4 | |
| Cortical neuron model | Focal hypoxia conditions | 4 each | |
| Cortical neuron model | Bulk hypoxia | 4 |
Experimental design.
The corrected Table 2 and its caption Experimental design appear below.
In the published article, there was an error in Table 3 as published. This was due to a formatting error during publication causing rows to become misplaced in the final printed copy.
TABLE 3
| Scavenging conditions (n = 3) | Measurand | Time (mins) | ||
|---|---|---|---|---|
| 0 | 30 | 180 | ||
| PBKCl PBKCl |
pH [H2O2] | 7.3 ± 0.1 Negative |
7.3 ± 0.1 0.8 ± 0.3 µM |
7.3 ± 0.1 0.8 ± 0.3 µM |
| PBKCl with catalase PBKCl with catalase |
pH [H2O2] | 7.3 ± 0.1 Negative |
7.3 ± 0.1 Negative |
7.2 ± 0.1 Negative |
| DMEM/F-12 DMEM/F-12 |
pH [H2O2] | 7.6 ± 0.1 Negative |
7.6 ± 0.1 0.8 ± 0.3 µM |
7.6 ± 0.1 Trace amount |
| DMEM/F-12 with catalase DMEM/F-12 with catalase |
pH [H2O2] | 7.4 ± 0.1 Negative |
7.4 ± 0.1 Negative |
7.4 ± 0.1 Negative |
pH and H2O2 concentration under eLOS oxygen scavenging.
The corrected Table 3 and its caption pH and H2O2 concentration under eLOS oxygen scavenging appear below.
Error in Table carried over to the index figure.
In the published article, there was an error in Index figure as published. This arose as a carry-over of the error in the formatting of the table that the publishers used as index figure A corrected index figure appears below corresponding to Figure 10 in the manuscript.
FIGURE 10
Focal hypoxia in a human cortical neuron microchannel model. (A) Schematic presentation of the microchannel model. Representative confocal tile image of neurons growing across the microchannels. Cyan: cell nucleus; green: axons. (B) Representative confocal image of cell nucleus (cyan) at the end chambers and axons in the central chamber after hypoxic insults. (C) Quantitative analysis of cells with chromatin condensation (n = 4).
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Statements
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
hypoxia, electrochemistry, microfluidic, human cortical neural progenitor, cortical neuron, axon, small vessel disease, lacunar infarct
Citation
Wong JJY, Varga BV, Káradóttir RT and Hall EAH (2023) Corrigendum: Electrochemically induced in vitro focal hypoxia in human neurons. Front. Cell Dev. Biol. 10:1118466. doi: 10.3389/fcell.2022.1118466
Received
07 December 2022
Accepted
08 December 2022
Published
05 January 2023
Approved by
Frontiers Editorial Office, Frontiers Media SA, Switzerland
Volume
10 - 2022
Updates
Copyright
© 2023 Wong, Varga, Káradóttir and Hall.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Elizabeth A. H. Hall, eah16@cam.ac.uk
This article was submitted to Cell Death and Survival, a section of the journal Frontiers in Cell and Developmental Biology
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.