Skip to main content

REVIEW article

Front. Cell Dev. Biol., 28 April 2023
Sec. Molecular and Cellular Pathology
This article is part of the Research Topic Artificial Intelligence Applications in Chronic Ocular Diseases View all 31 articles

Advances in artificial intelligence models and algorithms in the field of optometry

Suyu Wang,&#x;Suyu Wang1,2Yuke Ji,&#x;Yuke Ji1,2Wen Bai,&#x;Wen Bai1,2Yun JiYun Ji3Jiajun Li,Jiajun Li1,2Yujia Yao,Yujia Yao1,2Ziran Zhang,Ziran Zhang1,2Qin Jiang,
Qin Jiang1,2*Keran Li,
Keran Li1,2*
  • 1Department of Ophthalmology, The Affiliated Eye Hospital of Nanjing Medical University, Nanjing, China
  • 2The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China
  • 3Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China

The rapid development of computer science over the past few decades has led to unprecedented progress in the field of artificial intelligence (AI). Its wide application in ophthalmology, especially image processing and data analysis, is particularly extensive and its performance excellent. In recent years, AI has been increasingly applied in optometry with remarkable results. This review is a summary of the application progress of different AI models and algorithms used in optometry (for problems such as myopia, strabismus, amblyopia, keratoconus, and intraocular lens) and includes a discussion of the limitations and challenges associated with its application in this field.

1 Introduction

Artificial intelligence (AI) is a relatively new technology that endows machines with human behavior, thinking, and emotional abilities and can liberate human beings from tedious physical and mental labor and assist in the production and development of fields such as the economy, culture, and social life. AI, as a subfield of computer science, simulates human intelligence using algorithms that are developed using computers to engage in human work (Nuzzi et al., 2021). Machine learning (ML) is a research field of AI, which is a technology that allows computer systems to learn automatically from data and improve performance. Deep learning (DL) is a research field of ML, which is a representation learning algorithm based on artificial neural network. The relationship between AI, ML, and DL is shown in Figure 1. Current, commonly used AI algorithms include ML, DL, artificial neural networks, deep neural networks (DNNs), convolutional neural networks (CNNs), and migration learning. Over the past few years, the great development of computer science and technology has led to accelerated evolution in the field of AI, accelerating its application in medicine, especially ophthalmology. The first ophthalmic AI device, IDx-DR, was approved for listing with landmark significance on 11 April 2018, opening a new chapter on the combination of AI with ophthalmology. Since then, the application of AI in the ophthalmology has entered a new stage of development, leading to a series of satisfactory research results in the diagnosis, classification, recognition, and screening of ophthalmic diseases, such as diabetic retinopathy (Deepa et al., 2022; Hardas et al., 2022; Zhang et al., 2022), age-related macular degeneration (Glaret Subin and Muthukannan, 2022; Sotoudeh-Paima et al., 2022; Wang et al., 2022), retinopathy of prematurity (Coyner et al., 2022; Li et al., 2022; Wu et al., 2022), glaucoma (Dong et al., 2022; Li et al., 2022; Xiong et al., 2022), and retinal vein occlusion (Miao et al., 2022; Ren et al., 2022; Zhang et al., 2022).

FIGURE 1
www.frontiersin.org

FIGURE 1. Relationship between AI, ML, and DL.

The term optometry originated in the ancient Greek words optos (“see”) and metron (“measure”), indicating that it is closely related to “eyes” and “vision.” At the beginning of the 20th century, visual optics was defined as “studying the philosophy of light and vision,” and included a deep understanding of the connotation of the relationship between “light” and “vision”; By the middle of the 20th century, people understood optical vision as “the art of determining the visual state of normal people or correcting the abnormal state through glasses,” and the understanding and correction of vision became more specific. After hundreds of years of evolution and development, optometry has since developed rapidly. In terms of composition, the field of optometry mainly includes emmetropia, myopia, hyperopia, presbyopia, astigmatism, anisometropia, strabismus, amblyopia and so on, as shown in Figure 2. The continuous increase in the application of AI in the ophthalmology in recent years has achieved many remarkable research results. Here, we aimed to review the recent research results of using AI in the field of ophthalmic optometry over the past few years, with the challenges and limitations of AI in optometry applications discussed.

FIGURE 2
www.frontiersin.org

FIGURE 2. The basic composition of the field of optometry.

2 Application of AI models and algorithms in the field of optometry

In this section, we mainly review the research progress of AI in the field of optometry in the past 5 years. AI has carried out a lot of research in the field of optometry, especially in the diagnosis, screening and treatment of diseases. In recent years, with the continuous development and improvement of AI technology, the research of AI in the field of optics has become more in-depth and extensive. In order to better describe the basic flow of AI research, we take the DL model in Zheng et al. (2021) as an example, the basic flow of AI model research is illustrated in Figure 3. The process of developing an AI model involves deleting low-quality images and randomly dividing the remaining high-quality images into training and verification sets, with which the training set is optimized to obtain the best possible AI model and the performance is verified using the verification set.

FIGURE 3
www.frontiersin.org

FIGURE 3. Basic flow chart illustrating AI model research.

2.1 Application of AI models and algorithms in myopia

Myopia is a type of ametropia in which parallel light is focused on the front of the retina through the intraocular refractive medium and thus a clear image is not formed on the retina. The problem occurs mainly during childhood and early adulthood (Morgan et al., 2018). Although there is still much to learn about the etiology of myopia, the general consensus is that genetic, environmental, and biochemical variables play a role in the development of myopia. Myopia in children is mostly caused by a decline in outdoor playtime and an increase in time spent staring at screens. The mechanism of myopia progression mainly includes: 1) accommodative lag, 2) retinal peripheral defocus theory, 3) scleral thinning and ocular axial lengthening caused by extracellular matrix remodeling, 4) changes in the level of retinal nerve growth factor and inflammatory factors, etc. According to recent studies, alterations in the choroid’s thickness and function are also variables in the evolution of myopia. The choroid may operate as a barrier to the diffusion of endogenous growth hormones that encourage axial elongation. Adults over 50 can also develop nuclear myopia due to cataracts (Amirsolaimani et al., 2017; Bullimore and Brennan, 2019; Wong et al., 2021). The issue is thus a public health problem of widespread concern. High and pathological myopia can significantly increase the incidence of retinal detachment, myopic macular degeneration, macular choroidal neovascularization, and other diseases. According to statistics, more than 150 million people worldwide suffer from moderate to severe visual impairment due to uncorrected ametropia (Baird et al., 2020; Blindness G.B.D, 2021). At present, the main treatment methods are drug therapy (such as atropine eye drops), instrumental correction (such as frame glasses and keratoscopes), and surgical treatment (such as femtosecond pulsed or excimer lasers) (Li and Yam, 2019; Weiss and Park, 2019; Tsai et al., 2021). However, the complex causes and the large number of people affected renders large-scale screening and stratified analysis of myopia difficult, and the serious complications that are associated with the problem are generally not detected early enough for suitable intervention. It is therefore important that high-risk groups for high myopia are accurately identified and treated in a timely and effective manner to delay the progression of the disease. The development of AI for medical use has led to remarkable results in myopia prediction, diagnosis, screening, follow-up, and treatment (Gunasekeran et al., 2021). It can achieve effective data management and analysis, deeply excavating the inherent mechanisms by which myopia develops, and the big data storage function associated with AI is conducive to the accumulation of numerous individual experiences, thus playing an important auxiliary role in diagnosis and classification.

One development in the use of AI to diagnose myopia was made by Varadarajan et al. (2018), who constructed a DL model based on a residual network and a soft-attention layer and used it to analyze 226 870 fundus images. The model can predict spherical diopters, cylindrical diopters, and equivalent spherical equivalents by analyzing millions of parameters such as picture pixel values to judge the ametropia situation. A total of 39 757 fundus images were used to validate the model. The results showed average absolute errors of 0.56 D and 0.91 D, respectively, for the two data sets, realizing a technical leap in accurately predicting refractive errors from retinal fundus images. Lin et al. (2018) established an AI model that can predict myopia in children on the basis of a random forest algorithm using refractive data for 132 457 children from the electronic medical record database at eight eye centers, which were applied to training and verification. The model predicts myopia in children under 18 years of age by analyzing data such as age, spherical equivalent, and the annual myopia progression rate. The results showed an AUC between 0.940 and 0.985 for high myopia within 3 years, 0.856 and 0.901 within 5 years, and 0.801 and 0.837 within 8 years, indicating that the model can accurately predict the incidence of high myopia in school-age children at specific points in the future. In a studying the prediction of axial myopia, Tang et al. (2020) used six different ML algorithms to build an AI model that can predict axial length in children and optimized the AI model using cross-sectional datasets. The axial length for the children was predicted by analyzing variables such as sex, age, central corneal thickness, spherical equivalent error, K-means, and the black-and-white corneal diameter for 1,011 myopic children aged 6–18 years old. The results indicated that robust linear regression model had the best prediction result for eye-axis length, with an R 2 of 0.87, proving that the algorithm could be used to estimate the physiological components of eye axis growth and provide data support for separating non-physiological components from eye axis elongation for other therapeutic methods. To better predict adolescent myopia, Yang et al. (2020) used a support vector machine to establish a prediction model for juvenile myopia, using data from 3,112 pupils (including heredity, eye habit, environment, and diet) and constructed a dataset for training and testing the model using univariate and multivariate correlation analyses. The results showed an accuracy, specificity, sensitivity, and AUC of 0.93, 0.94, 0.94, and 0.98, respectively, for predicting myopia, proving that the model can comprehensively analyze several causes of myopia and can be used to help formulate myopia prevention and control policies. These studies indicate that AI has opened up a novel prediction model for myopia prediction through image and related data analysis that has high accuracy, is feasible for clinical application, and provides new ideas for myopia prevention and control. Foo et al. (2023) developed a deep learning system to identify children at risk of developing high myopia. In this study three distinct algorithms were derived (image, clinical and mix models) to predict the development of high myopia in adolescents after 5 years. 7,456 baseline fundus images were used for training and verification, 821 images with clinical data for external validation. Results showed that this DLS achieved a high accuracy with AUC all above 0.90, and can prevent the progression and complications of myopia in adulthood, help ophthalmologists to make clinical decisions.

Through analyzing eye images, AI can thus assist in the diagnosis and classification of myopia, improving the diagnostic efficiency and aiding ophthalmologists in screening for large-scale myopia while also facilitating the long-term follow-up of patients with high myopia, reducing the heavy burden caused by visual impairment and even blindness that can result from myopia. Sogawa et al. (2020) constructed several models using different DL algorithms (VGG16, VGG19, DenseNet121, InceptionV3 and ResNet50) and used them to analyze 910 eye optical coherence tomography (OCT) images. The experimental results showed that the AUC, sensitivity, and specificity for the DL model were 0.970, 0.906, and 0.942; the average correct classification rate for high myopia, myopic choroidal neovascularization, and retinoschisis images of 0.889 shows the feasibility of using these algorithm models in screening for single diseases and provides support for preventing vision loss in patients with myopic macular degeneration. To assist diagnosis of myopia in the clinical, Yang et al. (2020) constructed an AI diagnosis model using deep convolutional neural networks (DCNNs) and the VGG-Face algorithm. In this study, the eye appearance images of 2,350 children aged 6–18 years were collected from three angles; front, side, 45° anterior side, and spherical equivalent refraction was used to determine the refraction state of each eye from the images. The AUC, sensitivity, and specificity of the model for the diagnosis of myopia were 0.9270, 0.8113, and 0.8642, respectively, after training and verification, rendering vision screening possible without the need for examination, thus providing a more convenient method for routine vision screening. Hemelings et al. (2021) used the CNN to construct a DL model that can diagnose pathological myopia and used 1,200 color fundus images for the model training and testing. The final results showed that the AUC of the model for the diagnosis of pathological myopia was 0.9867. Li et al. (2023) collected 1,200 retinal fundus images to train a novel deep learning model on the basis of MyopiaDETR algorithm. This model using 2D fundus images as input, which can diagnose and discriminate different kinds of myopia such as normal myopia (NM), high myopia (HM) and pathological myopia (PM) through the analysis of the images. Besides, it has significant advantages over the traditional algorithms in terms of the accuracy and speed of the diagnosis. The results showed excellent localization and classification performance in the diagnosis of PM, reaching AP50 of 0.8632. Li et al. (2022) collected 412 OCT macular images of patients with high myopia and constructed an AI model based on the InceptionResnetV2 algorithm to identify four visual threats: retinoschisis, macular hole, retinal detachment, and pathological myopic choroidal neovascularization. The results showed an AUC of between 0.961 and 0.999 for the model, with both sensitivity and specificity reaching >0.90. These results show that AI is particularly accurate in diagnosing myopia and its complications and indicate that it can play an important role in large-scale myopia screening.

Refractive surgery, which can be divided into corneal refractive surgery and intraocular refractive surgery, is used to correct refractive errors in adult patients with stable myopia. At present, corneal refractive surgery comprises laser epithelial keratomileusis (LASEK), laser in situ keratomileusis (LASIK), and small-incision lens extraction (SMILE). Intraocular surgery includes lens implantation and cataract surgery. Some progress has also been made in the application of AI to preoperative screening and surgical planning for refractive surgery. Xie et al. (2020) constructed a DL model based on the InceptionResNetV2 algorithm used 6,465 corneal tomography images (including axial curvature, anterior corneal topography, posterior corneal topography, and corneal thickness) to train and test the model to screen potentially suitable patients for refractive surgery, with a screening accuracy of 0.947. Yoo et al. (2020) developed an ML model based on a multiclass XGBoost model that can select the best refractive surgery for patients with myopia. The algorithm can automatically extract 80 features from corneal topography and convert the numbers from the image into textual data. Eye examination data were collected from 18 480 myopic patients who planned to undergo refractive surgery and divided into the LASEK, LASIK, SMILE, and contraindication groups. The results showed accuracies of 0.810 and 0.789 for the internal and external verification datasets, respectively, indicating that it can synthesize ophthalmic data and select the most suitable operation plan at expert level. Wan et al. (2023) constructed a Deep learning model on basic of Resnet50 and XG Boost algorithms, aiming to Predict the early postoperative visual acuity after small-incision lenticule extraction surgery. In this study, 10,176 laser scanning images from the surgical videos were collected for training, and patients were classified by good or poor recovery. The results turned out with the accuracy of 0.96, AUC value of the DL model was 0.962–0.998. This model enables accurate prediction of early postoperative vision and complications only through surgical videos and pictures, which has an important influence on the application of AI in refractive surgery.

Contact lens Contact lens is a common adjuvant therapeutic tool in the field of optometry, includes rigid contact lens, soft contact lens and Orthokeratology (OK). Orthokeratology is a crucial component of clinical myopia management since it is a successful myopia control strategy. Nowadays, Orthokeratology (OK) is second only to muscarinic antagonists in terms of effectiveness in reducing childhood myopia. AI-assisted contact lens therapy is gradually becoming popular. In order to predict the curvature of orthokeratology lens, Fan et al. (2022) construct a machine learning model based on Linear Regression (Robust), Support Vector Machines (linear), Bagged Trees, Gaussian processes algorithms. Using sex, age, horizontal visible iris diameter (HVID), spherical refraction (SER), anterior chamber depth (ACD), axial length (AL) etc., of 1,271 patients with myopia as input variables, to estimate the alignment curve (AC) curvature of orthokeratology lens. Results indicated that the linear SVM and Gaussian process machine learning models achieves best performance, the R-squared values for the output AC1K1, AC1K2 and AC2K1 values were 0.91, 0.84, and 0.73. Prediction of orthokeratology lens curvature based on the ML model can reduce the number of lens trials, improve efficiency and accuracy, and reduce the probability of cross-infection caused by the test lens. By analyzing the clinical data of 1,037 Chinese myopic adolescents, Fan et al. (2021), developed a ML model on basic of Support vector machines (SVMs), Gaussian processes, Linear Regression (Robust) algorithms. This model is able to predict the return zone depth (RZD) and landing zone angle (LZA) of four quadrants of corneal refractive therapy (CRT) lenses under different combinations of age, sex and ocular parameters. Results showed that this model achieved higher accuracy, and is easier to use and faster to implement compared to the traditional sliding card method. To predict the treatment effect of orthokeratology, Fang et al. (2023) developed a ML model based on Logistic least absolute shrinkage and selection operator (LASSO) regression algorithm. The study collected the ocular parameters and clinical characteristics of 91 patients undergoing ortho-k treatment. It turned out that factors such as, lens wearing time, age, axial length, outdoor activity time, and white-to-white distance were strongly associated with treatment effects, with AUC values 0.949 and C-statistic of the predictive model was 0.821. This demonstrates how the ML model-based prediction of contact lens efficacy can help clinicians make clinical judgments and select more suitable treatment alternatives for patients. The above studies are summarized in Table 1.

TABLE 1
www.frontiersin.org

TABLE 1. Application summary of different AI models and algorithms used in myopia.

Myopia as a common refractive problem exists widely in adolescents and adults. Myopia tends to progress rapidly in adolescence. Variable degrees of fundus changes will also be present in individuals with high myopic in addition to vision loss, floaters, and flash sensations. The risk of retinal detachment, hiatus, fundus hemorrhage, and neovascularization is significantly higher than it is in healthy individuals. Therefore, early prediction and diagnosis of different types of myopia are of great significance for myopia treatment and prevention of complications. The prediction, classification diagnosis and auxiliary treatment of myopia based on artificial intelligence can greatly improve the diagnosis and treatment efficiency and accuracy of clinicians, and play an important role in the large-scale screening of myopia.

2.2 Application of AI models and algorithms in strabismus

Strabismus refers to any clinical phenomenon of visual axis deviation that can be caused by binocular abnormalities, neuromuscular abnormalities in eye movement control, or various other mechanical limitations (Sousa de Almeida et al., 2015). Strabismus can be divided into different types according to fusion state, eye movement and fixation, eye position, and age of occurrence (Castanes, 2003; Mojon-Azzi et al., 2011), and is commonly associated with visual development in children. Studies have shown that a prevalence of is 2%–4% for strabismus in children worldwide, which is significantly higher than observed in adults (Chia et al., 2010). One of the main issues with strabismus is that it can lead to abnormal visual functions such as strabismic amblyopia and seriously endanger the physical and mental health of infants and children, rendering timely diagnosis and treatment particularly important (Kelkar et al., 2015; Debert et al., 2016). At present, the common examination methods for strabismus in clinics include masking and cover-uncover tests, alternate cover tests, prism and cover tests, corneal reflection methods, synoptophore examinations, diagnostic strabismus tests, and eye movement traction tests (Chia et al., 2007; Wang et al., 2018; Yoo et al., 2019). Traditional strabismus diagnosis methods usually require manual examination by ophthalmologists, which is time-consuming and labor-intensive with subjective results. The application of AI technology in strabismus amblyopia has achieved muchand is thus expected to improve the current state of diagnosis and treatment for strabismus amblyopia.

Kang et al. (2022) constructed a DL model based on the U-Net network that can segment the cornea and scleral limbus and then classify the segmented eye region to realize automatic strabismus detection using 828 gaze photographs of strabismus patients with different eye positions used to train and verify the model. After verification, an accuracy of 0.9984 was obtained for corneal segmentation using the model, with a sensitivity of 0.9747, specificity of 0.9990, diameter similarity coefficient (DSC) of 0.9688, while the accuracy of limbal segmentation was 0.9992, with a sensitivity of 0.9563, specificity of 0.9996, and DSC of 0.9571. To develop a DL system that can assist in diagnosing strabismus, Mao et al. constructed a system based on InceptionResNetV2 using 5,797 corneal light reflection photos to develop, train, and verify the system (Mao et al., 2021). The system diagnoses strabismus by identifying different gaze states in reflective corneal photos. After training and testing, the experimental results showed sensitivity, specificity, and AUC of 0.991, 0.983 and 0.998 respectively, for the system. Another app that was developed by de de Figueiredo et al. (2021) based on the Resnet50 neural network can diagnose strabismus by identifying the different gaze positions of patients. The app was developed using gaze photos from 110 patients and the overall accuracy in the diagnosis of strabismus was between 0.42 and 0.92, with precision between 0.28 and 0.84. The above studies show that the AI model performs well in the auxiliary diagnosis of strabismus and has the potential for clinical application, where it may improve the accuracy of strabismus diagnosis and reduce the work pressure of clinicians.

Zheng et al. (2021) used a convolutional neural network and three deep convolution neural networks (Faster R-CNN, VGG16, Inception-V3, and Xception) to construct a DL model that can detect strabismus through the gaze of children using 7,530 primary gaze photos to develop, train, and verify the model. After external verification, a sensitivity of 0.940 was with a specificity of 0.993, AUC of 0.990, and accuracy of 0.950, for the model, which is better than that acquired by clinicians. Chen et al. (2018) constructed a DL model that can recognize strabismus using six different convolution neural networks (AlexNet, VGG-S, VGG-M, VGG-16, VGG-F, VGG-19). They collected gaze deviation images from 42 subjects and used them to train and verify the model. The results indicated that VGG-S had the best performance in recognizing strabismus, with a specificity of 0.960 and sensitivity of 0.941. Huang et al. (2022) constructed a strabismus screening and classification method based on the ResNet-12 network and used positive facial images from 60 subjects to train and test. This method identifies eye position in frontal facial images to diagnose strabismus and resulted in accuracy, sensitivity, and specificity for screening and classification values of 0.805, 0.768, and 0.842, respectively. To better assist in strabismus screening, Huang et al. (2021) constructed a DL model for strabismus screening based on the convolution neural network with 60 frontal facial images for training and verification. The experimental results showed that sample mean and standard deviation values for normal images of 1.073 ± 0.014 and 0.039, respectively, while those for strabismus images were 1.924 ± 0.169 and 0.472, respectively. The results of the above AI model in strabismus screening and recognition indicate that AI will likely be applied to strabismus screening in the future. The development of remote diagnosis methods for strabismus also overcomes limitations surrounding spatial distance, which is also significant for early detection and treatment in ophthalmopathy.

Liu et al. (2019) developed a DL model based on a support vector machine that can predict the time it will take for a patient to achieve visual function following strabismus surgery from the deviation angle of the eye position 1 day and 6 months after the operation. In this study, using the surgical data of 132 patients to train and test the model and a prediction accuracy of 0.821 was achieved. To aid patients with strabismus in selecting the best surgical treatment strategy, Almeida et al. (2015) proposed an AI method based on support vector regression, with the clinical data of 88 strabismus patients used to train and verify the method. This method can be used to decide the best surgical treatment strategies for strabismus patients according to the deviation degree, deviation type, visual acuity data, diopter, and fundus examination data of strabismus patients. Finally, the results showed that the average error in the proposed surgical treatment strategy was 0.5 mm for recoil and 0.7 for resection for medial rectus surgery while the mean error was 0.6 for recoil and 0.8 for resection in lateral rectus surgery, indicating that this method is feasible for use in planning strabismus surgery. Lou et al. (2022) constructed a novel recurrent residual CNN with global attention gate based on GAR2U-Net to automatically evaluate the Inferior oblique overaction (IOOA). This study included 106 eyes of 72 consecutive patients, and the height difference between the inferior corneal limbus of both eyes were measured. The results showed significant correlations measurements and clinical gradings. The new method allows for objective, accurate and reproducible IOOA measurements and has obvious advantages such as low cost, easy acquisition and wide measurement range compared with conventional methods. The above studies are summarized in Table 2.

TABLE 2
www.frontiersin.org

TABLE 2. Application summary of different AI models and algorithms used for strabismus.

Strabismus as a common eye disease, if not timely diagnosis and treatment, may lead to significant vision loss or even blindness. More importantly, strabismus will bring serious psychological burden to patients, resulting in many adverse consequences. Therefore, it is very important for timely diagnosis and treatment of strabismus. The above AI studies show that AI can play an important role in the diagnosis of strabismus. It can not only diagnose strabismus without ophthalmologist, but also significantly reduce the cost of diagnosis.

2.3 Application of AI models and algorithms in keratoconus

Keratoconus (KC) is a non-inflammatory corneal disease characterized by thinning of the corneal stroma, anterior protrusion, and irregular astigmatism. Thinning occurs in or near the center of the cornea, with subtemporal thinning the most common (Romero-Jiménez et al., 2013; Sharif et al., 2018). The prevalence rate of KC is approximately 1/2000–1/500, and it usually occurs during puberty, generally in one eye, with early symptoms including blurred vision and photophobia. Visual acuity declines progressively as the disease progresses, with irregular corneal astigmatism, monocular diplopia, and even irreversible vision loss observed (Jones-Jordan et al., 2013; Mostovoy et al., 2018; Flockerzi et al., 2021). The etiology and causes of this disease have not yet been clarified; however, studies have suggested that it may be related to structural changes in the corneal collagen tissue (Kankariya et al., 2013). Early diagnosis of KC is difficult, and is generally made by comprehensive analysis of the corneal topography and biomechanical characteristics during evaluation (Randleman et al., 2008; Santodomingo-Rubido et al., 2022). Currently, contact lenses, corneal cross-linking treatment, keratoplasty, and several other methods are used to treat the disorder (Godefrooij et al., 2017; Röck et al., 2018; Ferdi et al., 2019); however, corneal transplantation can lead to rejection, complicated cataracts, iris atrophy, secondary glaucoma, and other problems (Shah et al., 2010). Therefore, the early detection of KC and timely intervention are of great significance in controlling the progress of the disease and maintaining good vision. AI models that are useful in diagnosing KC have so far been established using SVM, decision tree, CNN, multilayer perception neutral networks (MLPNN), and feed forward neural networks (FNN), all of which have been found helpful in the early diagnosis of KC (artificial intelligence and corneal diseases, 2022).

Combining corneal topography with AI was found useful in improving the accuracy of KC diagnosis. Using three types of convolution neural networks (ResNet152, VGG16Net, Inception v3), Kuo et al. (2020) constructed a DL model that can diagnose KC and 359 corneal topographic maps were used to train and verify the model. The results showed sensitivities and specificities of >0.90 for all the CNN models, of which ResNet152 exhibited the best diagnostic performance with an AUC value of 0.995. Al-Timemy et al. (2021) constructed an AI model that can diagnose KC based on the hybrid DL algorithm using 3,794 corneal images (divided into normal cornea, suspected KC, and keratoconus). According to data describing the anterior and posterior eccentricity, anterior and posterior sagittal arc, and corneal thickness, corneal features were extracted for training and verification of the AI model, with results indicating AUC values of 0.99 and 0.93 and accuracies of 0.988 and 0.815, respectively, for KC. Compared with the previous single CNN model, which is sometimes highly sensitive to slight disturbances in the pixels comprising the input image, the hybrid algorithm provides more reliable results. Zéboulon et al. (2020) established an ML model based on a CNN to diagnose KC. They collected 3,000 corneal topography maps (normal corneal topography, KC topography, and corneal topography with a history of refractive surgery) and used the data of anterior corneal height map, posterior corneal height map, anterior keratometry map, and corneal thickness map for training and testing. After testing, the results showed that the accuracy of the model was as high as 0.993 in diagnosing KC, and thus has potential for application in clinical practice. Kamiya et al. (2021) constructed a DL model for diagnosing normal corneas and KC based on the VGG-16 neural network, using 519 corneal topographic images that were coded by color to train and test the model. The results showed that the model performed well in diagnosing KC, with an accuracy of 0.966, sensitivity of 0.988, and specificity of 0.944. Using CNNs, Kato et al. (2021) constructed an AI model that could predict the progress of KC. In this study, 274 corneal tomography images were collected and before and after anterior keratogram and corneal thickness images combined to form the training set and test set of DL model. measured to form the training and test sets for the DL model. The results showed that AUC, sensitivity, and specificity values of 0.81, 0.78, and 0.70, respectively, for predicting KC progression. The above research results illustrate the usefulness of using AI for the auxiliary diagnosis of KC, for which it can significantly improve the accuracy of a diagnosis, save time, and provide the best treatment for patients.

AI can help ophthalmologists effectively distinguish KC from normal corneas and classify diseases by analyzing the corneal shape and thickness, among other parameters. In order to assist KC classification, Feng et al. (2021) created a DL algorithm (KerNet algorithm). They used 854 corneal images together with original data such as the anterior and posterior surface curvature, anterior and posterior surface topography, and corneal thickness to form a numerical matrix for the training and verification of the algorithm. The results showed that the algorithm could achieve better results than the most advanced methods in detecting and classifying KC, especially subclinical KC, with an accuracy of 0.95. To distinguish KC from subclinical KC and normal cornea, Abdelmotaal et al. (2020) constructed a DL model based on a CNN and collected 3,218 corneal images for training and testing. The model can be realized using a single image for highly accurate KC classification, with an average of 0.983, and the fact that less computing resources are required renders this model advantageous in terms of applicability to large-scale disease screening without sufficient data. Aatila et al. (2021) constructed some DL models using a variety of algorithms (random forest classifier, Gaussian naive Bayes classifier, K neighbors classifier, logistic regression, linear discriminant analysis, decision tree classifier, and support vector machine) for the classification of KC. They used 12 242 corneal topography maps to compare the classification performance of the different DL models. The results indicated that random forest had the best classification performance, with an accuracy as high as 0.95. Cao et al. (2020) constructed an AI model that can distinguish subclinical KC from non-KC based on a variety of DL algorithms (random forest, decision tree, logistic regression, support vector machine, linear discriminant analysis, multilayer perceptron neural network, lasso regression, and k-nearest neighbor). Corneal parameters of 49 subclinical KC and 39 control eyes were analyzed, with diagnostic results showing an AUC of 0.97 for the random forest random forest model. This indicates that selecting a combination of important parameters from a larger set of parameters would lead to more objective and effective KC screening when constructing a ML model, rendering it a useful tool in clinical practice. The above studies are summarized in Table 3.

TABLE 3
www.frontiersin.org

TABLE 3. Application summary of different AI models and algorithms in keratoconus.

Late keratoconus often leads to severe vision loss or even blindness in patients. Early and timely treatment can effectively alleviate the progression of keratoconus and protect patients’ vision. Therefore, for patients with keratoconus, early diagnosis and timely treatment are very important. The above AI studies show that AI has carried out a lot of research in the diagnosis, classification and prediction of keratoconus, and the AI model has shown good performance. AI model can provide great help to doctors in the clinical diagnosis of keratoconus, and automatically complete the relevant diagnosis and treatment work, so as to reduce the workload of doctors, which has important clinical significance to improve the efficiency of doctors.

2.4 Application of AI models and algorithms in the preoperative measurement and effect prediction of intraocular lenses

An intraocular lens (IOL) is a special lens made of synthetic materials that can replace the human lens (Lundström et al., 2018). The development of cataract surgery and the demand for high visual quality has meant that cataract surgery has evolved from visual rehabilitation to accurate refractive surgery with high visual quality (Piovella et al., 2019). The choice of intraocular lens has also gradually diversified from unifocal to functional intraocular lenses (Simon et al., 2014). The postoperative visual acuity of patients depends to a large extent on accurate biometric and IOL diopter calculations prior to operating. However, the changes that occur in the intraocular structure of some patients before surgery renders calculation of the IOL diopter difficult, and postoperative complications can easily occur in surgery for issues such as high myopia (Savini and Hoffer, 2018; Yao et al., 2021). In addition, the abnormal position of the IOL that can result from various factors will seriously affect visual quality after surgery (Wang et al., 2022). In recent years, IOL calculation methods based on AI have shown good performance and been proved able to effectively improve the accuracy of IOL diopter calculations (Wang et al., 2016; Melles et al., 2019; Nemeth et al., 2022). At the same time, a variety of methods such as slit-lamp photography, slit-lamp video photography, and OCT can be combined to determine the location of the IOL (Mura et al., 2010; Omoto et al., 2022).

Using AI in designing the IOL calculation formula can improve the accuracy of the calculation according to the characteristics of different patients so that better visual quality can be obtained following surgery. Mori et al. (2021) constructed an ML model based on a support vector regression algorithm to adapt the diopter calculation method for intraocular lens in a specific patient population to improve the accuracy of the calculation. By analyzing the clinical data for 11 611 eyes with a single monofocal IOL implantation model, the constants of the SRK/T and Haigis formulas were optimized and the support vector regression algorithm was used to adapt the SRK/T, Haigis, Hill-RBF, and Barrett Universal II formulas. The results showed a smaller average error in the optimized formula for calculating the IOL diopter than that obtained using the other formulas (p < 0.001). To improve the accuracy in calculating the IOL degree for high myopia, Wei et al. (2020) developed an AI calculation model based on the XGBoost regression algorithm. They collected data from 1,564 high myopia eyes for training and verification and combined a constant IOL diopter with the Barrett Universal II formula and other data, they developed a new IOL calculation method. The results showing significant decreases in the median absolute and median square errors as compared to those obtained under the BUII formula (p ≤ 0.001), and the proportion of eyes with prediction errors within ±0.25D increased significantly. Cabeza-Gil et al. (2020) proposed two intraocular lens calculation models based on the DNN algorithm to calculate the biomechanical stability of IOL which were then verified using data from 37,161 cases. Six parameters (length, width, thickness, opening angle of the haptic, tactility, and haptic-optic junction in the reference data) were used to enhance the consistency of patient characteristics so as to improve the success rate of the operation. The results showed Pearson’s r values of 0.995 and 0.992 for the two models; indicating good performance. Clarke and Kapelner (2020) designed a more accurate diopter calculation model for the intraocular lens, Bayesian Additive Regression Trees (BART), which was based on the ML algorithm. They collected measurement data from 5,331 eyes divided into training and verification subsets based on the specific characteristics of patients and their eyes. The results showed an average absolute error of 0.204 D, proving that the diopter of the intraocular lens calculated by this model was more accurate than that obtained by other commonly used formulas.

The calculation formula for the IOL has undergone several generations of evolution at different times. The first-generation formula is based only on regression data, while the second-generation formula includes the influencing factor of axis length and the third-generation formula refers to optics and IOL position factors. Methods for formula optimization are now more abundant, and combined with artificial intelligence, the accuracy of IOL calculation has been much improved. Guillaume et al. (2021) constructed an ML model based on the multiple linear regression algorithm to improve the IOL formula and constructed the new PEARL-DGS formula to calculate the diopter of IOLs by analyzing the data of 4,242 intraocular lens implants. The examination data of another 677 eyes were collected and compared with the K6 and Olsen, EVO 2.0, RBF 3.0, and BUII formulas, with results showing the smallest calculation error when using the PEARL-DGS formula with an error range of ±0.382 D, which indicates that completely retraining the formula, rather than the conventional constant adjustment, can allow adaption to the habits of doctors and the characteristics of specific patient groups. Ladas et al. (2021) constructed an AI model based on DL algorithms (extreme gradient boosting, support vector regression, artificial neural network) to optimize the existing diopter calculation formula for intraocular lens and develop a new hybrid formula based on AI. They analyzed the eye data of 1,391 patients who underwent IOL implantation, with the factor axial length, anterior chamber depth, lens thickness, sex, age, and postoperative significant diopter considered, and determined both the average absolute error in each IOL formula and the number of eyes that predicted diopter within 0.5 D. After AI optimization, the average percentage of eyes within ±0.5 D predicted by the SRK formula increased to 14%, the Holladay 1 formula increased by 9.3% and the LSF formula increased by 5.3% (p < 0.05), while in terms of average absolute error, the predicted diopter of optimized SRK formula decreased to 0.14 D, the Holladay 1 formula decreased to 0.08D and the LSF formula decreased to0.04D.

In the process of intraocular lens implantation, the influence that location and the size of the anterior and posterior space have on visual quality and postoperative complications can easily be ignored. An IOL localization method based on AI can effectively solve this problem. Schwarzenbacher et al. (2022) used a CNN to construct a DL model that can automatically divide the IOL, Retrolental, and Berger’s space and analyze the spatial resolution to accurately locate the target structure. In the study, a total of 92 eye OCT images were used to train and varify the model, with results indicating Precision, Recall, and Dice scores of 0.97, 0.90, and 0.93, respectively, indicating that the model has high accuracy in locating the IOL. This is the first time that this type of algorithm has been proposed to automatically segment the posterior structure of the anterior segment. To evaluate the position of the IOL in three-dimensional space, Xin et al. (2020) constructed an AI evaluation model based on a region-based fully convolutional network (R-FCN), with 86 AS-OCT images used to train and verify the model. The results showed an evaluation efficiency of 0.910 for the model, with intraclass correlation coefficients (ICC) of 0.867 and 0.901 for reliability and repeatability, respectively, evaluating the location of the IOL in a three-dimensional space to provide data support for the design of a better functional IOL. The above studies are summarized in Table 4.

TABLE 4
www.frontiersin.org

TABLE 4. Application of different AI models and algorithms in intraocular lens calculation and postoperative prediction.

Intraocular lens implantation is a common method of ocular surgery. Patients’ postoperative visual acuity is highly correlated with their accurate preoperative biometric features and IOL diopter calculation. AI-based IOL diopter calculation can effectively improve the accuracy and help solve some cases with complicated intraocular structure. In addition, artificial intelligence can assist in determining the location of IOL implantation, which plays an important role in improving patients’ visual quality and reducing postoperative complications.

2.5 Application of AI models and algorithms in amblyopia

Amblyopia is a decrease in monocular or binocular best-corrected visual acuity that leads to abnormal visual experiences (monocular strabismus, anisometropia, high ametropia, and form deprivation) during visual development (Kates and Beal, 2021). Factors that cause amblyopia include ametropia, strabismus, anisometropia, ptosis, lens opacity, and form deprivation (Paff et al., 2010; Rajavi et al., 2012; Barrett et al., 2013). According to its etiology, amblyopia is mainly divided into strabismic, anisometropic, ametropic, and form deprivation amblyopia (Maurer and K. S., 2018; Birch, 2013). Amblyopia can be mild, moderate, or severe. The main manifestations of amblyopia are lower than normal best-corrected visual acuity, crowding, paracentric fixation, prolonged PVEP latency, and decreased amplitude of visual evoked potentials (Lempert, 2006; Hess and Thompson, 2015). At present, the main treatment strategy for amblyopia is to remove the factors that cause deprivation as soon as possible, with cataract treatment, complete ptosis correction, the use of appropriate corrective glasses, covering healthy eyes, and optical drug suppression therapy all used (Birch et al., 2021; Boniquet-Sanchez and Sabater-Cruz, 2021; Meier and Tarczy-Hornoch, 2022). According to the law of visual development, early detection, diagnosis, and intervention are particularly important for patients with amblyopia, and can significantly improve the therapeutic effects (Holmes and Levi, 2018).

Murali et al. (2020) constructed a DL model based on a CNN for screening the risk factors for amblyopia in children. This model can identify biological characteristics such as corneal light reflection, iris center position, pupil radius, and ratio of eye radius to iris diameter from the facial image, allowing easy screening of the risk factors in children. They collected facial images of 54 participants to train and test the model, with results indicating an accuracy of 0.796, sensitivity of 0.882, specificity of 0.756, and an F-score of 0.732. Murali et al. (2021) collected facial images of 654 participants (randomly divided into training and verification sets) and constructed a DL model that could screen and identify the risk factors of amblyopia in children based on a convolution neural network. After verification, the values of 0.908, 0.836, and 0.859, respectively, for accuracy, sensitivity, and specificity indicate that the use of DL to analyze photographic images is an effective alternative method for screening risk factors in children with amblyopia. The above studies show that using AI to recognize the biological features of children’s facial images allows accurate detection of the risk factors for amblyopia, which is of great significance for amblyopic children. The above studies are summarized in Table 5.

TABLE 5
www.frontiersin.org

TABLE 5. Application summary of different AI models and algorithms in amblyopia.

Amblyopia is a common eye disease in children. for amblyopic children, the therapeutic effect is closely related to age, and the younger the age, the better the therapeutic effect. In addition, early treatment not only has a short course of treatment, but also has a significantly higher cure rate. Therefore, it is particularly important to screen the risk factors of amblyopia in children. Through the above research, we can see that AI shows a good performance in the screening of risk factors of amblyopia in children. Its use in the screening of risk factors of amblyopia in children can not only save manpower, material and financial resources, but also is of great significance for the early treatment of children with amblyopia.

3 Limitations and challenges

As can be seen from the above studies, AI has been widely used in optometry. Many AI models and algorithms have shown superior performance in the diagnosis, identification, screening, prediction, and treatment of disease with satisfactory results achieved. However, there remain many challenges and limitations that are likely to seriously affect further research and the application of AI in the field of optometry. For example, 1) The quality of the image in the data set (Ting et al., 2019; Xie et al., 2020). The datasets used in some studies are public, and include many poor-quality images. Because the research results of the AI model are closely related to image quality, this issue will significantly impact the AI model, resulting in inaccurate results. 2) Sample size (Chen et al., 2018; Huang et al., 2021; Gutierrez et al., 2022; Huang et al., 2022). The small sample size in some studies is likely to affect the stability of the AI model, affecting the reliability of the results. For example, in some AI studies of strabismus, amblyopia and other diseases, the sample size in the data set is small, which will have a certain impact on the performance of the final AI model. 3) External verification of the algorithm (Wawer Matos et al., 2022; Wong et al., 2022). Some AI models have excellent performance in training and verification; however, there is a huge gap between the “real environment” and the “research environment”, which may lead to performance degradation and produce unstable results when such AI models are applied to clinical diagnosis and treatment. For example, in the research of strabismus, keratoconus and other diseases, many AI models are verified only on external data sets, but not in the “real environment.” 4) Validity of the datasets (Ting et al., 2019; Ng et al., 2021). The images used in many studies need to be annotated, with strict requirements for labeling l. The validity of the data used is particularly important for the research results of an AI model. For example, in some studies, the task of image annotation is completed by residents, which may be difficult to ensure the accuracy of image annotation, thus affecting the performance of the AI model. 5) Interpretability of AI algorithms (Al-Aswad et al., 2022; Betzler et al., 2022). Because AI belongs to a subfield of computer science, many clinical medical staff have little AI-related knowledge, which leads to incorrect interpretation in the process of clinical application, resulting in the so-called “black box phenomenon.” 6) AI model may lead to medical legal problems (Ji et al., 2022). No one is perfect, and artificial intelligence cannot be 100% accurate. When the diagnosis of the AI model is wrong or even has serious consequences, how to determine its behavior? Who should bear the consequences? These will become some thorny medical legal issues. 7) The privacy and security of patients (Murdoch, 2021). Medical data focus on patients’ health, disease status, biological genes and other information, once leaked, the consequences are unimaginable. The privacy security problems of medical artificial intelligence are as follows: do patients fully get their informed consent in the process of data collection? In the event of a privacy leak, who will be held responsible? Who has the right to get information about a patient’s health or disease? These are all important and urgent problems to be solved. 8) The lack of legal protection related to AI technology. In recent years, the rapid development of AI technology has greatly changed our lives. However, the legislative process for artificial intelligence is relatively slow. Artificial intelligence needs to have corresponding laws and regulations in all aspects of research and development, development and production process, and stipulate the ownership of responsibility and the direction of development; artificial intelligence (especially deep learning) if there is no legal escort, will seriously affect its development and application.

4 Conclusion

Through the above AI research, it can be found that many research achievements have been made in the application of AI in the field of optics, and the application prospect is very broad, which can bring reform and progress to the field of optics in many aspects. Intelligent systems based on different AI algorithms can help ophthalmologists better diagnose and treat diseases in the field of optometry according to patients’ eye clinical data and personal data, which has important clinical significance. But for clinical medical staff, only this is far from enough. Because this shallow clinical application plays a more auxiliary role, such as reducing the repetitive physical labor of clinical medical personnel, improving the accuracy of diagnosis and so on. If we want to fully apply AI to ophthalmic clinic, AI must have more functions. It can not only complete the assigned tasks, but also develop more technologies and methods according to the characteristics of each task. In addition, AI also needs to pay more attention to those unsolved technologies and challenges, so as to better promote the clinical application of AI in ophthalmology.

As mentioned in this review, AI can complete specified tasks by building algorithm models and DL networks, particularly image recognition, classification, diagnosis, and data analysis. Although there are still several challenges associated with AI modeling, it can provide doctors with objective clinical decisions, laying the foundation for accurate treatment. There is an urgent need for future research into the unknown aspects of target diseases, which combined with application, could instigate targeted and high-quality research. Simultaneously, the introduction and application of a number of standardized norms are that can further improve the quality of AI medical research and promote AI products will provide great advantages in the diagnosis and treatment of optometry-related diseases as soon as possible.

5 Resource identification initiative

PubMed (RRID:SCR_004846).

Author contributions

SW and YJ carried out the studies and drafted the manuscript. WB participated in data collection. KL and QJ participated in the study design and guidance. All authors read and approved the final manuscript.

Funding

This study was supported by the National Natural Science Foundation of China (82171080, 82101155), Nanjing Medical Science and Technology Development Project (YKK19157), and Postgraduate Research & Practice Innovation Program of Jiangsu Province (JX10413973).

Acknowledgments

The authors would like to thank the Affiliated Eye Hospital of Nanjing Medical University for supporting the research work.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

References

Aatila, M., Lachgar, M., Hamid, H., and Kartit, A. (2021). Keratoconus severity classification using features selection and machine learning algorithms. Comput. Math. Methods Med. 2021, 9979560. doi:10.1155/2021/9979560

PubMed Abstract | CrossRef Full Text | Google Scholar

Abdelmotaal, H., Mostafa, M. M., Mostafa, A. N. R., Mohamed, A. A., and Abdelazeem, K. (2020). Classification of color-coded Scheimpflug camera corneal tomography images using deep learning. Transl. Vis. Sci. Technol. 9, 30. doi:10.1167/tvst.9.13.30

PubMed Abstract | CrossRef Full Text | Google Scholar

Al-Aswad, L. A., Ramachandran, R., Schuman, J. S., Medeiros, F., and Eydelman, M. B., and Collaborative Community for Ophthalmic Imaging Executive Committee and Glaucoma Workgroup (2022). Artificial intelligence for glaucoma: Creating and implementing artificial intelligence for disease detection and progression. Ophthalmol. Glaucoma. 5, e16–e25. doi:10.1016/j.ogla.2022.02.010

PubMed Abstract | CrossRef Full Text | Google Scholar

Almeida, J. D., Silva, A. C., Teixeira, J. A., Paiva, A. C., and Gattass, M. (2015). Surgical planning for horizontal strabismus using Support Vector Regression. Comput. Biol. Med. 63, 178–186. doi:10.1016/j.compbiomed.2015.05.025

PubMed Abstract | CrossRef Full Text | Google Scholar

Al-Timemy, A. H., Mosa, Z. M., Alyasseri, Z., Lavric, A., Lui, M. M., Hazarbassanov, R. M., et al. (2021). A hybrid deep learning construct for detecting keratoconus from corneal maps. Transl. Vis. Sci. Technol. 10, 16. doi:10.1167/tvst.10.14.16

PubMed Abstract | CrossRef Full Text | Google Scholar

Amirsolaimani, B., Peyman, G., Schwiegerling, J., Bablumyan, A., and Peyghambarian, N. (2017). A new low-cost, compact, auto-phoropter for refractive assessment in developing countries. Sci. Rep. 7, 13990. doi:10.1038/s41598-017-14507-5

PubMed Abstract | CrossRef Full Text | Google Scholar

Baird, P. N., Saw, S. M., Lanca, C., Guggenheim, J. A., Smith, E. L., Zhou, X., et al. (2020). Myopia. Nat. Rev. Dis. Prim. 6, 99. doi:10.1038/s41572-020-00231-4

PubMed Abstract | CrossRef Full Text | Google Scholar

Barrett, B. T., Bradley, A., and Candy, T. R. (2013). The relationship between anisometropia and amblyopia. Prog. Retin. Eye Res. 36, 120–158. doi:10.1016/j.preteyeres.2013.05.001

PubMed Abstract | CrossRef Full Text | Google Scholar

Betzler, B. K., Rim, T. H., Sabanayagam, C., and Cheng, C. Y. (2022). Artificial intelligence in predicting systemic parameters and diseases from ophthalmic imaging. Front. Digit. Health. 4, 889445. doi:10.3389/fdgth.2022.889445

PubMed Abstract | CrossRef Full Text | Google Scholar

Birch, E. E., Kelly, K. R., and Wang, J. (2021). Recent advances in screening and treatment for amblyopia. Ophthalmol. Ther. 10, 815–830. doi:10.1007/s40123-021-00394-7

PubMed Abstract | CrossRef Full Text | Google Scholar

Birch, E. E. (2013). Amblyopia and binocular vision. Prog. Retin. Eye Res. 33, 67–84. doi:10.1016/j.preteyeres.2012.11.001

PubMed Abstract | CrossRef Full Text | Google Scholar

Boniquet-Sanchez, S., and Sabater-Cruz, N. (2021). Current management of amblyopia with new technologies for binocular treatment. Vis. (Basel) 5, 31. doi:10.3390/vision5020031

CrossRef Full Text | Google Scholar

Bullimore, M. A., and Brennan, N. A. (2019). Myopia control: Why each diopter matters. Optom. Vis. Sci. 96, 463–465. doi:10.1097/OPX.0000000000001367

PubMed Abstract | CrossRef Full Text | Google Scholar

Cabeza-Gil, I., Ríos-Ruiz, I., and Calvo, B. (2020). Customised selection of the haptic design in C-loop intraocular lenses based on deep learning. Ann. Biomed. Eng. 48, 2988–3002. doi:10.1007/s10439-020-02636-4

PubMed Abstract | CrossRef Full Text | Google Scholar

Cao, K., Verspoor, K., Sahebjada, S., and Baird, P. N. (2020). Evaluating the performance of various machine learning algorithms to detect subclinical keratoconus. Transl. Vis. Sci. Technol. 9, 24. doi:10.1167/tvst.9.2.24

PubMed Abstract | CrossRef Full Text | Google Scholar

Castanes, M. S. (2003). Major review: The underutilization of vision screening (for amblyopia, optical anomalies and strabismus) among preschool age children. Binocul. Vis. Strabismus Q. 18, 217–232.

PubMed Abstract | Google Scholar

Chen, Z., Fu, H., Lo, W. L., and Chi, Z. (2018). Strabismus recognition using eye-tracking data and convolutional neural networks. J. Healthc. Eng. 2018, 7692198. doi:10.1155/2018/7692198

PubMed Abstract | CrossRef Full Text | Google Scholar

Chia, A., Roy, L., and Seenyen, L. (2007). Comitant horizontal strabismus: An Asian perspective. Br. J. Ophthalmol. 91, 1337–1340. doi:10.1136/bjo.2007.116905

PubMed Abstract | CrossRef Full Text | Google Scholar

Chia, A., Dirani, M., Chan, Y. H., Gazzard, G., Au Eong, K. G., Selvaraj, P., et al. (2010). Prevalence of amblyopia and strabismus in young Singaporean Chinese children. Invest. Ophthalmol. Vis. Sci. 51, 3411–3417. doi:10.1167/iovs.09-4461

PubMed Abstract | CrossRef Full Text | Google Scholar

Clarke, G. P., and Kapelner, A. (2020). The bayesian additive regression trees formula for safe machine learning-based intraocular lens predictions. Front. Big Data. 3, 572134. doi:10.3389/fdata.2020.572134

PubMed Abstract | CrossRef Full Text | Google Scholar

Coyner, A. S., Oh, M. A., Shah, P. K., Singh, P., Ostmo, S., Valikodath, N. G., et al. (2022). External validation of a retinopathy of prematurity screening model using artificial intelligence in 3 low- and middle-income populations. JAMA Ophthalmol. 140, 791–798. doi:10.1001/jamaophthalmol.2022.2135

PubMed Abstract | CrossRef Full Text | Google Scholar

de Figueiredo, L. A., Dias, J. V. P., Polati, M., Carricondo, P. C., and Debert, I. (2021). Strabismus and artificial intelligence app: Optimizing diagnostic and accuracy. Transl. Vis. Sci. Technol. 10, 22. doi:10.1167/tvst.10.7.22

PubMed Abstract | CrossRef Full Text | Google Scholar

Debellemanière, G., Dubois, M., Gauvin, M., Wallerstein, A., Brenner, L. F., Rampat, R., et al. (2021). The PEARL-DGS formula: The development of an open-source machine learning-based thick IOL calculation formula. Am. J. Ophthalmol. 232, 58–69. doi:10.1016/j.ajo.2021.05.004

PubMed Abstract | CrossRef Full Text | Google Scholar

Debert, I., Miller, J. M., Danh, K. K., and Scott, A. B. (2016). Pharmacologic injection treatment of comitant strabismus. J. AAPOS. 20, 106–111. doi:10.1016/j.jaapos.2015.11.011

PubMed Abstract | CrossRef Full Text | Google Scholar

Deepa, V., Sathish Kumar, C., and Cherian, T. (2022). Automated grading of diabetic retinopathy using CNN with hierarchical clustering of image patches by Siamese network. Phys. Eng. Sci. Med. 45, 623–635. doi:10.1007/s13246-022-01129-z

PubMed Abstract | CrossRef Full Text | Google Scholar

Dong, L., He, W., Zhang, R., Ge, Z., Wang, Y. X., Zhou, J., et al. (2022). Artificial intelligence for screening of multiple retinal and optic nerve diseases. JAMA Netw. Open. 5, e229960. doi:10.1001/jamanetworkopen.2022.9960

PubMed Abstract | CrossRef Full Text | Google Scholar

Fan, Y., Yu, Z., Peng, Z., Xu, Q., Tang, T., Wang, K., et al. (2020). Machine learning based strategy surpasses the traditional method for selecting the first trial Lens parameters for corneal refractive therapy in Chinese adolescents with myopia. CONTACT LENS ANTERIO 44 (3), 101330. doi:10.1016/j.clae.2020.05.001

PubMed Abstract | CrossRef Full Text | Google Scholar

Fan, Y., Yu, Z., Tang, T., Liu, X., Xu, Q., Peng, Z., et al. (2021). Machine learning algorithm improves accuracy of ortho-K lens fitting in vision shaping treatment. CONTACT LENS ANTERIO 45 (3), 101474. doi:10.1016/j.clae.2021.101474

CrossRef Full Text | Google Scholar

Fang, J., Zheng, Y., Mou, H., Shi, M., Yu, W., and Du, C. (2023). Machine learning for predicting the treatment effect of orthokeratology in children. Front. Pediatr. 10, 1057863. doi:10.3389/fped.2022.1057863

PubMed Abstract | CrossRef Full Text | Google Scholar

Feng, R., Xu, Z., Zheng, X., Hu, H., Jin, X., Chen, D. Z., et al. (2021). KerNet: A novel deep learning approach for keratoconus and sub-clinical keratoconus detection based on raw data of the pentacam hr system. IEEE J. Biomed. Health Inf. 25, 3898–3910. doi:10.1109/JBHI.2021.3079430

CrossRef Full Text | Google Scholar

Ferdi, A. C., Nguyen, V., Gore, D. M., Allan, B. D., Rozema, J. J., and Watson, S. L. (2019). Keratoconus natural progression: A systematic review and meta-analysis of 11 529 eyes. Ophthalmology 126, 935–945. doi:10.1016/j.ophtha.2019.02.029

PubMed Abstract | CrossRef Full Text | Google Scholar

Flockerzi, E., Xanthopoulou, K., Goebels, S. C., Zemova, E., Razafimino, S., Hamon, L., et al. (2021). Keratoconus staging by decades: A baseline abcd classification of 1000 patients in the homburg keratoconus center. Br. J. Ophthalmol. 105, 1069–1075. doi:10.1136/bjophthalmol-2020-316789

PubMed Abstract | CrossRef Full Text | Google Scholar

Foo, L. L., Lim, G. Y. S., Lanca, C., Wong, C. W., Hoang, Q. V., Zhang, X. J., et al. (2023). Deep learning system to predict the 5-year risk of high myopia using fundus imaging in children. NPJ Digit. Med. 6 (1), 10. doi:10.1038/s41746-023-00752-8

PubMed Abstract | CrossRef Full Text | Google Scholar

GBD 2019 Blindness and Vision Impairment Collaborators, Vision Loss Expert Group of the Global Burden of Disease Study (2021). Trends in prevalence of blindness and distance and near vision impairment over 30 years: An analysis for the Global Burden of Disease Study. Vision Impairment, and S. Lancet Glob. Health. 9, e130–e143. doi:10.1016/S2214-109X(20)30425-3

PubMed Abstract | CrossRef Full Text | Google Scholar

Glaret Subin, P., and Muthukannan, P. (2022). Optimized convolution neural network based multiple eye disease detection. Comput. Biol. Med. 146, 105648. doi:10.1016/j.compbiomed.2022.105648

PubMed Abstract | CrossRef Full Text | Google Scholar

Godefrooij, D. A., Mangen, M. J., Chan, E., O’Brart, D. P. S., Imhof, S. M., de Wit, G. A., et al. (2017). Cost-effectiveness analysis of corneal collagen crosslinking for progressive keratoconus. Ophthalmology 124, 1485–1495. doi:10.1016/j.ophtha.2017.04.011

PubMed Abstract | CrossRef Full Text | Google Scholar

Gunasekeran, D. V., Tseng, R. M. W. W., Tham, Y. C., and Wong, T. Y. (2021). Applications of digital health for public health responses to COVID-19: A systematic scoping review of artificial intelligence, telehealth and related technologies. NPJ Digit. Med. 4, 40. doi:10.1038/s41746-021-00412-9

PubMed Abstract | CrossRef Full Text | Google Scholar

Gutierrez, L., Lim, J. S., Foo, L. L., Ng, W. Y., Yip, M., Lim, G. Y. S., et al. (2022). Application of artificial intelligence in cataract management: Current and future directions. Eye Vis. (Lond). 9, 3. doi:10.1186/s40662-021-00273-z

PubMed Abstract | CrossRef Full Text | Google Scholar

Hardas, M., Mathur, S., Bhaskar, A., and Kalla, M. (2022). Retinal fundus image classification for diabetic retinopathy using SVM predictions. Phys. Eng. Sci. Med. 45, 781–791. doi:10.1007/s13246-022-01143-1

PubMed Abstract | CrossRef Full Text | Google Scholar

Hemelings, R., Elen, B., Blaschko, M. B., Jacob, J., Stalmans, I., and De Boever, P. (2021). Pathological myopia classification with simultaneous lesion segmentation using deep learning. Comput. Methods Programs Biomed. 199, 105920. doi:10.1016/j.cmpb.2020.105920

PubMed Abstract | CrossRef Full Text | Google Scholar

Hess, R. F., and Thompson, B. (2015). Amblyopia and the binocular approach to its therapy. Vis. Res. 114, 4–16. doi:10.1016/j.visres.2015.02.009

PubMed Abstract | CrossRef Full Text | Google Scholar

Holmes, J. M., and Levi, D. M. (2018). Treatment of amblyopia as a function of age. Vis. Neurosci. 35, E015. doi:10.1017/S0952523817000220

PubMed Abstract | CrossRef Full Text | Google Scholar

Huang, X., Lee, S. J., Kim, C. Z., and Choi, S. H. (2021). An automatic screening method for strabismus detection based on image processing. PLOS ONE 16, e0255643. doi:10.1371/journal.pone.0255643

PubMed Abstract | CrossRef Full Text | Google Scholar

Huang, X., Lee, S. J., Kim, C. Z., and Choi, S. H. (2022). An improved strabismus screening method with combination of meta-learning and image processing under data scarcity. PLOS ONE 17, e0269365. doi:10.1371/journal.pone.0269365

PubMed Abstract | CrossRef Full Text | Google Scholar

Ji, Y., Chen, N., Liu, S., Yan, Z., Qian, H., Zhu, S., et al. (2022). Research progress of artificial intelligence image analysis in systemic disease-related ophthalmopathy. Dis. Markers 2022, 3406890. doi:10.1155/2022/3406890

PubMed Abstract | CrossRef Full Text | Google Scholar

Jones-Jordan, L. A., Walline, J. J., Sinnott, L. T., Kymes, S. M., and Zadnik, K. (2013). Asymmetry in keratoconus and vision-related quality of life. Cornea 32, 267–272. doi:10.1097/ICO.0b013e31825697c4

PubMed Abstract | CrossRef Full Text | Google Scholar

Kamiya, K., Ayatsuka, Y., Kato, Y., Shoji, N., Mori, Y., and Miyata, K. (2021). Diagnosability of keratoconus using deep learning with Placido disk-based corneal topography. Front. Med. (Lausanne). 8, 724902. doi:10.3389/fmed.2021.724902

PubMed Abstract | CrossRef Full Text | Google Scholar

Kang, L., Ballouz, D., and Woodward, M. A. (2022)., 33. PMID, 407–417. Artificial intelligence and corneal diseasesCurr. Opin. Ophthalmol. doi:10.1097/ICU.0000000000000885

PubMed Abstract | CrossRef Full Text | Google Scholar

Kang, Y. C., Yang, H. K., Kim, Y. J., Hwang, J. M., and Kim, K. G. (2022). Automated mathematical algorithm for quantitative measurement of strabismus based on photographs of nine cardinal gaze positions. Biomed. Res. Int. 2022, 9840494. doi:10.1155/2022/9840494

PubMed Abstract | CrossRef Full Text | Google Scholar

Kankariya, V. P., Kymionis, G. D., Diakonis, V. F., and Yoo, S. H. (2013). Management of pediatric keratoconus - evolving role of corneal collagen cross-linking: An update. Indian J. Ophthalmol. 61, 435–440. doi:10.4103/0301-4738.116070

PubMed Abstract | CrossRef Full Text | Google Scholar

Kates, M. M., and Beal, C. J. (2021). Amblyopia. JAMA. 325, 408. doi:10.1001/jama.2020.5741

CrossRef Full Text

Kato, N., Masumoto, H., Tanabe, M., Sakai, C., Negishi, K., Torii, H., et al. (2021). Predicting keratoconus progression and need for corneal crosslinking using deep learning. J. Clin. Med. 10, 844. doi:10.3390/jcm10040844

PubMed Abstract | CrossRef Full Text | Google Scholar

Kelkar, J. A., Gopal, S., Shah, R. B., and Kelkar, A. S. (2015). Intermittent exotropia: Surgical treatment strategies. Indian J. Ophthalmol. 63, 566–569. doi:10.4103/0301-4738.167109

PubMed Abstract | CrossRef Full Text | Google Scholar

Kuo, B. I., Chang, W. Y., Liao, T. S., Liu, F. Y., Liu, H. Y., Chu, H. S., et al. (2020). Keratoconus screening based on deep learning approach of corneal topography. Transl. Vis. Sci. Technol. 9, 53. doi:10.1167/tvst.9.2.53

PubMed Abstract | CrossRef Full Text | Google Scholar

Ladas, J., Ladas, D., Lin, S. R., Devgan, U., Siddiqui, A. A., and Jun, A. S. (2021). Improvement of multiple generations of intraocular lens calculation formulae with a novel approach using artificial intelligence. Transl. Vis. Sci. Technol. 10, 7. doi:10.1167/tvst.10.3.7

PubMed Abstract | CrossRef Full Text | Google Scholar

Lempert, P. (2006). Relationship between anisometropia, patient age, and the development of amblyopia. Am. J. Ophthalmol. 142, 891–892. author reply 891–891; author reply 892. doi:10.1016/j.ajo.2006.07.059

PubMed Abstract | CrossRef Full Text | Google Scholar

Li, F. F., and Yam, J. C. (2019). Low-concentration atropine eye drops for myopia progression. Asia Pac. J. Ophthalmol. (Phila). 8, 360–365. doi:10.1097/APO.0000000000000256

PubMed Abstract | CrossRef Full Text | Google Scholar

Li, F., Su, Y., Lin, F., Li, Z., Song, Y., Nie, S., et al. (2022). A deep-learning system predicts glaucoma incidence and progression using retinal photographs. J. Clin. Invest. 132, e157968. doi:10.1172/JCI157968

PubMed Abstract | CrossRef Full Text | Google Scholar

Li, J., Huang, K., Ju, R., Chen, Y., Li, M., Yang, S., et al. (2022). Evaluation of artificial intelligence-based quantitative analysis to identify clinically significant severe retinopathy of prematurity. Retina 42, 195–203. doi:10.1097/IAE.0000000000003284

PubMed Abstract | CrossRef Full Text | Google Scholar

Li, Y., Feng, W., Zhao, X., Liu, B., Zhang, Y., Chi, W., et al. (2022). Development and validation of a deep learning system to screen vision-threatening conditions in high myopia using optical coherence tomography images. Br. J. Ophthalmol. 106, 633–639. doi:10.1136/bjophthalmol-2020-317825

PubMed Abstract | CrossRef Full Text | Google Scholar

Li, M., Liu, S., Wang, Z., Li, X., Yan, Z., Zhu, R., et al. (2023). MyopiaDETR: End-to-end pathological myopia detection based on transformer using 2D fundus images. Front. Neurosci. 17, 1130609. doi:10.3389/fnins.2023.1130609

PubMed Abstract | CrossRef Full Text | Google Scholar

Lin, H., Long, E., Ding, X., Diao, H., Chen, Z., Liu, R., et al. (2018). Prediction of myopia development among Chinese school-aged children using refraction data from electronic medical records: A retrospective, multicentre machine learning study. PLOS Med. 15, e1002674. doi:10.1371/journal.pmed.1002674

PubMed Abstract | CrossRef Full Text | Google Scholar

Liu, Y., Liu, C., Zhang, W., Chen, X., and Zhao, K. (2019). Model of a support vector machine to assess the functional cure for surgery of intermittent exotropia. Sci. Rep. 9, 8321. doi:10.1038/s41598-019-38969-x

PubMed Abstract | CrossRef Full Text | Google Scholar

Lou, L., Huang, X., Sun, Y., Cao, J., Wang, Y., Zhang, Q., et al. (2022). Automated photographic analysis of inferior oblique overaction based on deep learning. Quant. Imag. Med. Surg. 13 (1), 329–338. doi:10.21037/qims-22-467

CrossRef Full Text | Google Scholar

Lundström, M., Dickman, M., Henry, Y., Manning, S., Rosen, P., Tassignon, M. J., et al. (2018). Risk factors for refractive error after cataract surgery: Analysis of 282 811 cataract extractions reported to the European Registry of Quality Outcomes for cataract and refractive surgery. J. Cataract. Refract. Surg. 44, 447–452. doi:10.1016/j.jcrs.2018.01.031

PubMed Abstract | CrossRef Full Text | Google Scholar

Mao, K., Yang, Y., Guo, C., Zhu, Y., Chen, C., Chen, J., et al. (2021). An artificial intelligence platform for the diagnosis and surgical planning of strabismus using corneal light-reflection photos. Ann. Transl. Med. 9, 374. doi:10.21037/atm-20-5442

PubMed Abstract | CrossRef Full Text | Google Scholar

Maurer, D., and McKEE, S. P. (2018). Classification and diversity of amblyopia. Vis. Neurosci. 35, E012. doi:10.1017/S0952523817000190

PubMed Abstract | CrossRef Full Text | Google Scholar

Meier, K., and Tarczy-Hornoch, K. (2022). Recent treatment advances in amblyopia. Annu. Rev. Vis. Sci. 8, 323–343. doi:10.1146/annurev-vision-100720-022550

PubMed Abstract | CrossRef Full Text | Google Scholar

Melles, R. B., Kane, J. X., Olsen, T., and Chang, W. J. (2019). Update on intraocular lens calculation formulas. Ophthalmology 126, 1334–1335. doi:10.1016/j.ophtha.2019.04.011

PubMed Abstract | CrossRef Full Text | Google Scholar

Miao, J., Yu, J., Zou, W., Su, N., Peng, Z., Wu, X., et al. (2022). Deep learning models for segmenting non-perfusion area of color fundus photographs in patients with branch retinal vein occlusion. Front. Med. (Lausanne). 9, 794045. doi:10.3389/fmed.2022.794045

PubMed Abstract | CrossRef Full Text | Google Scholar

Mojon-Azzi, S. M., Kunz, A., and Mojon, D. S. (2011). The perception of strabismus by children and adults. Graefes Arch. Clin. Exp. Ophthalmol. 249, 753–757. doi:10.1007/s00417-010-1555-y

PubMed Abstract | CrossRef Full Text | Google Scholar

Morgan, I. G., French, A. N., Ashby, R. S., Guo, X., Ding, X., He, M., et al. (2018). The epidemics of myopia: Aetiology and prevention. Prog. Retin. Eye Res. 62, 134–149. doi:10.1016/j.preteyeres.2017.09.004

PubMed Abstract | CrossRef Full Text | Google Scholar

Mori, Y., Yamauchi, T., Tokuda, S., Minami, K., Tabuchi, H., and Miyata, K. (2021). Machine learning adaptation of intraocular lens power calculation for a patient group. Eye Vis. (Lond). 8, 42. doi:10.1186/s40662-021-00265-z

PubMed Abstract | CrossRef Full Text | Google Scholar

Mostovoy, D., Vinker, S., Mimouni, M., Goldich, Y., Levartovsky, S., and Kaiserman, I. (2018). The association of keratoconus with blepharitis. Clin. Exp. Optom. 101, 339–344. doi:10.1111/cxo.12643

PubMed Abstract | CrossRef Full Text | Google Scholar

Mura, J. J., Pavlin, C. J., Condon, G. P., Belovay, G. W., Kranemann, C. F., Ishikawa, H., et al. (2010). Ultrasound biomicroscopic analysis of iris-sutured foldable posterior chamber intraocular lenses. Am. J. Ophthalmol. 149, 245–252. doi:10.1016/j.ajo.2009.08.022

PubMed Abstract | CrossRef Full Text | Google Scholar

Murali, K., Krishna, V., Krishna, V., and Kumari, B. (2020). Application of deep learning and image processing analysis of photographs for amblyopia screening. Indian J. Ophthalmol. 68, 1407–1410. doi:10.4103/ijo.IJO_1399_19

PubMed Abstract | CrossRef Full Text | Google Scholar

Murali, K., Krishna, V., Krishna, V., Kumari, B., Raveendra Murthy, S., Vidhya, C., et al. (2021). Effectiveness of Kanna photoscreener in detecting amblyopia risk factors. Indian J. Ophthalmol. 69, 2045–2049. doi:10.4103/ijo.IJO_2912_20

PubMed Abstract | CrossRef Full Text | Google Scholar

Murdoch, B. (2021). Privacy and artificial intelligence: Challenges for protecting health information in a new era. BMC Med. Ethics 22 (1), 122. doi:10.1186/s12910-021-00687-3

PubMed Abstract | CrossRef Full Text | Google Scholar

Nemeth, G., Kemeny-Beke, A., and Modis, L. (2022). Comparison of accuracy of different intraocular lens power calculation methods using artificial intelligence. Eur. J. Ophthalmol. 32, 235–241. doi:10.1177/1120672121994720

PubMed Abstract | CrossRef Full Text | Google Scholar

Ng, W. Y., Zhang, S., Wang, Z., Ong, C. J. T., Gunasekeran, D. V., Lim, G. Y. S., et al. (2021). Updates in deep learning research in ophthalmology. Clin. Sci. (Lond.). 135, 2357–2376. doi:10.1042/CS20210207

PubMed Abstract | CrossRef Full Text | Google Scholar

Nuzzi, R., Boscia, G., Marolo, P., and Ricardi, F. (2021). The impact of artificial intelligence and deep learning in eye diseases: A review. Front. Med. (Lausanne). 8, 710329. doi:10.3389/fmed.2021.710329

PubMed Abstract | CrossRef Full Text | Google Scholar

Omoto, M., Sugawara, K., Torii, H., Yotsukura, E., Masui, S., Shigeno, Y., et al. (2022). Investigating the prediction accuracy of recently updated intraocular lens power formulas with artificial intelligence for high myopia. J. Clin. Med. 11, 4848. doi:10.3390/jcm11164848

PubMed Abstract | CrossRef Full Text | Google Scholar

Paff, T., Oudesluys-Murphy, A. M., Wolterbeek, R., Swart-van den Berg, M., de Nie, J. M., Tijssen, E., et al. (2010). Screening for refractive errors in children: The plusoptiX S08 and the Retinomax K-plus2 performed by a lay screener compared to cycloplegic retinoscopy. J. AAPOS. 14, 478–483. doi:10.1016/j.jaapos.2010.09.015

PubMed Abstract | CrossRef Full Text | Google Scholar

Piovella, M., Colonval, S., Kapp, A., Reiter, J., Van Cauwenberge, F., and Alfonso, J. (2019). Patient outcomes following implantation with a trifocal toric IOL: Twelve-month prospective multicentre study. Eye (Lond.). 33, 144–153. doi:10.1038/s41433-018-0076-5

PubMed Abstract | CrossRef Full Text | Google Scholar

Rajavi, Z., Parsafar, H., Ramezani, A., and Yaseri, M. (2012). Is noncycloplegic photorefraction applicable for screening refractive amblyopia risk factors? J. Ophthalmic Vis. Res. 7, 3–9.

PubMed Abstract | Google Scholar

Randleman, J. B., Woodward, M., Lynn, M. J., and Stulting, R. D. (2008). Risk assessment for ectasia after corneal refractive surgery. Ophthalmology 115, 37–50. doi:10.1016/j.ophtha.2007.03.073

PubMed Abstract | CrossRef Full Text | Google Scholar

Ren, X., Feng, W., Ran, R., Gao, Y., Lin, Y., Fu, X., et al. (2022). Artificial intelligence to distinguish retinal vein occlusion patients using color fundus photographs. Eye (Lond). doi:10.1038/s41433-022-02239-4

CrossRef Full Text | Google Scholar

Röck, T., Bartz-Schmidt, K. U., and Röck, D. (2018). Trends in corneal transplantation at the university eye hospital in tubingen, Germany over the last 12 years: 2004–2015. PLOS ONE 13, e0198793. doi:10.1371/journal.pone.0198793

PubMed Abstract | CrossRef Full Text | Google Scholar

Romero-Jiménez, M., Santodomingo-Rubido, J., and González-Méijome, J. M. (2013). The thinnest, steepest, and maximum elevation corneal locations in noncontact and contact lens wearers in keratoconus. Cornea 32, 332–337. doi:10.1097/ICO.0b013e318259c98a

PubMed Abstract | CrossRef Full Text | Google Scholar

Santodomingo-Rubido, J., Carracedo, G., Suzaki, A., Villa-Collar, C., Vincent, S. J., and Wolffsohn, J. S. (2022). Keratoconus: An updated review. Cont. Lens Anterior Eye. 45, 101559. doi:10.1016/j.clae.2021.101559

PubMed Abstract | CrossRef Full Text | Google Scholar

Savini, G., and Hoffer, K. J. (2018). Intraocular lens power calculation in eyes with previous corneal refractive surgery. Eye Vis. (Lond). 5, 18. doi:10.1186/s40662-018-0110-5

PubMed Abstract | CrossRef Full Text | Google Scholar

Schwarzenbacher, L., Seeböck, P., Schartmüller, D., Leydolt, C., Menapace, R., and Schmidt-Erfurth, U. (2022). Automatic segmentation of intraocular lens, the retrolental space and Berger’s space using deep learning. Acta Ophthalmol. 100, e1611–e1616. doi:10.1111/aos.15141

PubMed Abstract | CrossRef Full Text | Google Scholar

Shah, A. K., Terry, M. A., Shamie, N., Chen, E. S., Phillips, P. M., Hoar, K. L., et al. (2010). Complications and clinical outcomes of descemet stripping automated endothelial keratoplasty with intraocular lens exchange. Am. J. Ophthalmol. 149, 390–397. doi:10.1016/j.ajo.2009.11.002

PubMed Abstract | CrossRef Full Text | Google Scholar

Sharif, R., Bak-Nielsen, S., Hjortdal, J., and Karamichos, D. (2018). Pathogenesis of keratoconus: The intriguing therapeutic potential of prolactin-inducible protein. Prog. Retin. Eye Res. 67, 150–167. doi:10.1016/j.preteyeres.2018.05.002

PubMed Abstract | CrossRef Full Text | Google Scholar

Simon, S. S., Chee, Y. E., Haddadin, R. I., Veldman, P. B., Borboli-Gerogiannis, S., Brauner, S. C., et al. (2014). Achieving target refraction after cataract surgery. Ophthalmology 121, 440–444. doi:10.1016/j.ophtha.2013.09.022

PubMed Abstract | CrossRef Full Text | Google Scholar

Sogawa, T., Tabuchi, H., Nagasato, D., Masumoto, H., Ikuno, Y., Ohsugi, H., et al. (2020). Accuracy of a deep convolutional neural network in the detection of myopic macular diseases using swept-source optical coherence tomography. PLOS ONE 15, e0227240. doi:10.1371/journal.pone.0227240

PubMed Abstract | CrossRef Full Text | Google Scholar

Sotoudeh-Paima, S., Jodeiri, A., Hajizadeh, F., and Soltanian-Zadeh, H. (2022). Multi-scale convolutional neural network for automated AMD classification using retinal OCT images. Comput. Biol. Med. 144, 105368. doi:10.1016/j.compbiomed.2022.105368

PubMed Abstract | CrossRef Full Text | Google Scholar

Sousa de Almeida, J. D., Silva, A. C., Teixeira, J. A., Paiva, A. C., and Gattass, M. (2015). Computer-aided methodology for syndromic strabismus diagnosis. J. Digit. Imaging. 28, 462–473. doi:10.1007/s10278-014-9758-0

PubMed Abstract | CrossRef Full Text | Google Scholar

Tang, T., Yu, Z., Xu, Q., Peng, Z., Fan, Y., Wang, K., et al. (2020). A machine learning-based algorithm used to estimate the physiological elongation of ocular axial length in myopic children. Eye Vis. (Lond). 7, 50. doi:10.1186/s40662-020-00214-2

PubMed Abstract | CrossRef Full Text | Google Scholar

Ting, D. S. W., Pasquale, L. R., Peng, L., Campbell, J. P., Lee, A. Y., Raman, R., et al. (2019). Artificial intelligence and deep learning in ophthalmology. Br. J. Ophthalmol. 103, 167–175. doi:10.1136/bjophthalmol-2018-313173

PubMed Abstract | CrossRef Full Text | Google Scholar

Ting, D. S. W., Peng, L., Varadarajan, A. V., Keane, P. A., Burlina, P. M., Chiang, M. F., et al. (2019). Deep learning in ophthalmology: The technical and clinical considerations. Prog. Retin. Eye Res. 72, 100759. doi:10.1016/j.preteyeres.2019.04.003

PubMed Abstract | CrossRef Full Text | Google Scholar

Tsai, H. R., Chen, T. L., Wang, J. H., Huang, H. K., and Chiu, C. J. (2021). Is 0.01% atropine an effective and safe treatment for myopic children? A systemic review and meta-analysis. J. Clin. Med. 10, 3766. doi:10.3390/jcm10173766

PubMed Abstract | CrossRef Full Text | Google Scholar

Varadarajan, A. V., Poplin, R., Blumer, K., Angermueller, C., Ledsam, J., Chopra, R., et al. (2018). Deep learning for predicting refractive error from retinal fundus images. Invest. Ophthalmol. Vis. Sci. 59, 2861–2868. doi:10.1167/iovs.18-23887

PubMed Abstract | CrossRef Full Text | Google Scholar

Wan, Q., Yue, S., Tang, J., Wei, R., Tang, J., Ma, K., et al. (2023). Prediction of early visual outcome of small-incision lenticule extraction (SMILE) based on deep learning. Ophthalmol. Ther. 12 (2), 1263–1279. doi:10.1007/s40123-023-00680-6

PubMed Abstract | CrossRef Full Text | Google Scholar

Wang, W., Yan, W., Fotis, K., Prasad, N. M., Lansingh, V. C., Taylor, H. R., et al. (2016). Cataract surgical rate and socioeconomics: A global study. Invest. Ophthalmol. Vis. Sci. 57, 5872–5881. doi:10.1167/iovs.16-19894

PubMed Abstract | CrossRef Full Text | Google Scholar

Wang, K. J., Chang, Q. L., Man, F. Y., Ding, J., Wang, J. H., Xian, J. F., et al. (2018). Congenital monocular strabismus fixus. J. Pediatr. Ophthalmol. Strabismus. 55, 363–368. doi:10.3928/01913913-20180620-02

PubMed Abstract | CrossRef Full Text | Google Scholar

Wang, L., Jin, G., Zhang, J., Chen, X., Tan, X., Wang, W., et al. (2022). Clinically significant intraocular lens decentration and tilt in highly myopic eyes: A swept-source optical coherence tomography study. Am. J. Ophthalmol. 235, 46–55. doi:10.1016/j.ajo.2021.08.017

PubMed Abstract | CrossRef Full Text | Google Scholar

Wang, W., Li, X., Xu, Z., Yu, W., Zhao, J., Ding, D., et al. (2022). Learning Two-Stream CNN for multi-modal age-related macular degeneration categorization. IEEE J. Biomed. Health Inf. 26, 4111–4122. doi:10.1109/JBHI.2022.3171523

CrossRef Full Text | Google Scholar

Wawer Matos, P. A., Reimer, R. P., Rokohl, A. C., Caldeira, L., Heindl, L. M., and Große Hokamp, N. (2022). Artificial intelligence in ophthalmology - Status quo and future perspectives. Semin. Ophthalmol. 38, 226–237. –12. doi:10.1080/08820538.2022.2139625

PubMed Abstract | CrossRef Full Text | Google Scholar

Wei, L., Song, Y., He, W., Chen, X., Ma, B., Lu, Y., et al. (2020). Accuracy improvement of IOL power prediction for highly myopic eyes with an XGBoost machine learning-based calculator. Front. Med. (Lausanne). 7, 592663. doi:10.3389/fmed.2020.592663

PubMed Abstract | CrossRef Full Text | Google Scholar

Weiss, R. S., and Park, S. (2019). Recent updates on myopia control: Preventing progression 1 diopter at a time. Curr. Opin. Ophthalmol. 30, 215–219. doi:10.1097/ICU.0000000000000571

PubMed Abstract | CrossRef Full Text | Google Scholar

Wong, C. W., Tsai, A., Jonas, J. B., Ohno-Matsui, K., Chen, J., Ang, M., et al. (2021). Digital screen time during the COVID-19 pandemic: Risk for a further myopia boom? Am. J. Ophthalmol. 223, 333–337. doi:10.1016/j.ajo.2020.07.034

PubMed Abstract | CrossRef Full Text | Google Scholar

Wong, D. Y. L., Lam, M. C., Ran, A., and Cheung, C. Y. (2022). Artificial intelligence in retinal imaging for cardiovascular disease prediction: Current trends and future directions. Curr. Opin. Ophthalmol. 33, 440–446. doi:10.1097/ICU.0000000000000886

PubMed Abstract | CrossRef Full Text | Google Scholar

Wu, Q., Hu, Y., Mo, Z., Wu, R., Zhang, X., Yang, Y., et al. (2022). Development and validation of a deep learning model to predict the occurrence and severity of retinopathy of prematurity. JAMA Netw. Open. 5, e2217447. doi:10.1001/jamanetworkopen.2022.17447

PubMed Abstract | CrossRef Full Text | Google Scholar

Xie, Y., Zhao, L., Yang, X., Wu, X., Yang, Y., Huang, X., et al. (2020). Screening candidates for refractive surgery with corneal tomographic-based deep learning. JAMA Ophthalmol. 138, 519–526. doi:10.1001/jamaophthalmol.2020.0507

PubMed Abstract | CrossRef Full Text | Google Scholar

Xin, C., Bian, G. B., Zhang, H., Liu, W., and Dong, Z. (2020). Optical coherence tomography-based deep learning algorithm for quantification of the location of the intraocular lens. Ann. Transl. Med. 8, 872. doi:10.21037/atm-20-4706

PubMed Abstract | CrossRef Full Text | Google Scholar

Xiong, J., Li, F., Song, D., Tang, G., He, J., Gao, K., et al. (2022). Multimodal machine learning using visual fields and peripapillary circular OCT scans in detection of glaucomatous optic neuropathy. Ophthalmology 129, 171–180. doi:10.1016/j.ophtha.2021.07.032

PubMed Abstract | CrossRef Full Text | Google Scholar

Yang, X., Chen, G., Qian, Y., Wang, Y., Zhai, Y., Fan, D., et al. (2020). Prediction of myopia in adolescents through machine learning methods. Int. J. Environ. Res. Public Health. 17, 463. doi:10.3390/ijerph17020463

PubMed Abstract | CrossRef Full Text | Google Scholar

Yang, Y., Li, R., Lin, D., Zhang, X., Li, W., Wang, J., et al. (2020). Automatic identification of myopia based on ocular appearance images using deep learning. Ann. Transl. Med. 8, 705. doi:10.21037/atm.2019.12.39

PubMed Abstract | CrossRef Full Text | Google Scholar

Yao, Y., Lu, Q., Wei, L., Cheng, K., Lu, Y., and Zhu, X. (2021). Efficacy and complications of cataract surgery in high myopia. J. Cataract. Refract. Surg. 47, 1473–1480. doi:10.1097/j.jcrs.0000000000000664

PubMed Abstract | CrossRef Full Text | Google Scholar

Yoo, Y. J., Yang, H. K., Seo, J. M., Kim, K. G., and Hwang, J. M. (2019). Infrared photographs with a selective wavelength filter to diagnose small-angle esotropia in young children. Graefes Arch. Clin. Exp. Ophthalmol. 257, 645–650. doi:10.1007/s00417-019-04240-2

PubMed Abstract | CrossRef Full Text | Google Scholar

Yoo, T. K., Ryu, I. H., Choi, H., Kim, J. K., Lee, I. S., Kim, J. S., et al. (2020). Explainable machine learning approach as a tool to understand factors used to select the refractive surgery technique on the expert level. Transl. Vis. Sci. Technol. 9, 8. doi:10.1167/tvst.9.2.8

PubMed Abstract | CrossRef Full Text | Google Scholar

Zéboulon, P., Debellemanière, G., Bouvet, M., and Gatinel, D. (2020). Corneal topography raw data classification using a convolutional neural network. Am. J. Ophthalmol. 219, 33–39. doi:10.1016/j.ajo.2020.06.005

PubMed Abstract | CrossRef Full Text | Google Scholar

Zhang, G., Sun, B., Zhang, Z., Wu, S., Zhuo, G., Rong, H., et al. (2022). Hypermixed convolutional neural network for retinal vein occlusion classification. Dis. Markers. 2022, 1730501. doi:10.1155/2022/1730501

PubMed Abstract | CrossRef Full Text | Google Scholar

Zhang, W. F., Li, D. H., Wei, Q. J., Ding, D. Y., Meng, L. H., Wang, Y. L., et al. (2022). The validation of deep learning-based grading model for diabetic retinopathy. Front. Med. (Lausanne). 9, 839088. doi:10.3389/fmed.2022.839088

PubMed Abstract | CrossRef Full Text | Google Scholar

Zheng, C., Yao, Q., Lu, J., Xie, X., Lin, S., Wang, Z., et al. (2021). Detection of referable horizontal strabismus in children’s primary gaze photographs using deep learning. Transl. Vis. Sci. Technol. 10, 33. The following formatting styles are meant as a guide, as long as the full citation is complete and clear, Frontiers referencing style will be applied during typesetting.

CrossRef Full Text | Google Scholar

Keywords: artificial intelligence, optometry, myopia, strabismus, amblyopia, corneal conus, artificial lens

Citation: Wang S, Ji Y, Bai W, Ji Y, Li J, Yao Y, Zhang Z, Jiang Q and Li K (2023) Advances in artificial intelligence models and algorithms in the field of optometry. Front. Cell Dev. Biol. 11:1170068. doi: 10.3389/fcell.2023.1170068

Received: 27 February 2023; Accepted: 17 April 2023;
Published: 28 April 2023.

Edited by:

Yanwu Xu, Baidu, China

Reviewed by:

Jinhai Huang, Fudan University, China
Yifan Xiang, Sun Yat-sen University, China
Tae Keun Yoo, B&VIIT Eye center/Refractive surgery & AI Center, Republic of Korea
Qi Dai, Wenzhou Medical University, China

Copyright © 2023 Wang, Ji, Bai, Ji, Li, Yao, Zhang, Jiang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Qin Jiang, anFpbjcxMEB2aXAuc2luYS5jb20=; Keran Li, a2F0aHlrZXJhbjg2MDMyN0AxMjYuY29t

These authors share first authorship

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.