Non-coding RNAs (ncRNAs) including long non-coding RNAs (lncRNAs), micro RNAs (miRNAs), and circular RNAs (circRNAs) are emerging as key players in regulating tumorigenesis. Though these ncRNAs do not encode for functional proteins, they can act epigenetically, transcriptionally, post transcriptionally or at translational and post translational levels to alter gene expression. Accumulating evidence suggests that lncRNAs alter gene expression during the development and metastasis of solid tumors. Importantly, these non-coding RNAs are also used as biomarkers in different cancers. This special edition presents a wide Research Topic of reviews that summarize recent work in this area.
CircRNAs are generated by back splicing from covalently closed loops. The first circRNA was reported in virus (Kolakofsky, 1976; Sanger et al., 1976). Three years later, circRNAs were identified in the cytoplasm of several eukaryotic cells by electron microscopy by Hsu and Coca-Prados (1979). With the advancement of high throughput sequencing and bioinformatics, in-depth analysis, and characterization of circular RNAs have been emerging. CircRNAs usually are more stable than linear ones and can be translated into small peptides through cap-independent manner. The recently identified approximately 1,500 circular RNA in mouse or rat genomes unravel the possibility of the identification of peptides. In humans, the first circRNA was detected in Hela cells in 1979. After that, various functions of circular RNAs have been implicated in a number of diseases and disorders such as diabetes, neurological disorders, cardiovascular diseases, and cancer. In cancer, multiple studies suggest that peptides synthesized from the circRNA, play a critical role in proliferation, invasion and migration of various cancer cells. Recently, a circRNA produced by the SNF2 histone linker PHD RING helicase (SHPRH) gene was reported to be associated with various cancers including lung, bladder, liver, and colorectal cancers, and glioma. The review article by Xiong et al. summarizes the role of circ-SHPRE in regulating gene expression in tumorigenesis and as a prognostic biomarker for the early detection of various solid cancers.
LncRNAs regulate the expression of genes post-transcriptionally. LncRNAs can also modulate nuclear organization, mRNA processing, and protein activities and thus are known to play diverse roles in regulating different stages of cancer development. Macha and his group in this Research Topic describe how lncRNAs regulate signaling pathways and modify the expression of genes to alter the tumour microenvironment to promote metastasis. They have provided a detailed mechanistic analysis on the interaction of lcnRNAs with the cancer microenvironment. Baba et al. also highlight the possible usage of lncRNAs in treating cancer.
These review articles focus on various functions of lncRNAs in regulating gene expression. LncRNAs are often considered as promising reagents for future therapeutics too. LncRNAs function as signaling molecules to regulate transcriptional activity, act as decoys to titrate away proteins or other regulatory RNAs or guide the localization of ribonucleoprotein complexes and as scaffolds to assemble ribonucleoprotein complexes. LncRNA can also act as endogenous competitive RNAs of miRNAs that share sequence identity and similarity with mRNA and can competitively bind to miRNAs to exert their function. CASC11 belongs to this class of lncRNA and functions as a critical tumor promoter in various cancers. Ghafouri-Fard et al. focused on recent advancements in understanding the role of CASC11 in carcinogenesis and its potential clinical applications.
MINC is another lncRNA, identified recently from the TCGA database. It is associated with different types of cancer. It regulates cell cycle, proliferation and apoptosis. Multiple lines of evidence demonstrate elevated level of this lncRNA in various cancers including gallbladder, hepatocellular, colorectal, nasopharyngeal and non-small cell lung cancer, and in oral squamous cell carcinoma and glioma. Chao et al. outline the deficiencies in our present knowledge of the field and potential ways to explain the function of this RNA in the context of its oncogenic and other related properties. The study also provides evidence that MINC is often considered a prognostic biomarker in various cancers.
In summary, this Research Topic focusses on the dynamic functions of ncRNAs in regulating development of metastasis of solid tumors and also highlights the potential therapeutic use of ncRNAs.
Statements
Author contributions
BR: Writing–review and editing. SD: Writing–review and editing. CM: Writing–original draft, Writing–review and editing.
Acknowledgments
We would like to thank all contributing authors who decided to publish their article and reviewers, and the journal editors for their enormous efforts to make the special Research Topic a success.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1
HsuM. T.Coca-PradosM. (1979). Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells. Nature280, 339–340. 10.1038/280339a0
2
KolakofskyD. (1976). Isolation and characterization of Sendai virus DI-RNAs. Cell8, 547–555. 10.1016/0092-8674(76)90223-3
3
SangerH. L.KlotzG.RiesnerD.GrossH. J.KleinschmidtA. K. (1976). Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc. Natl. Acad. Sci. U. S. A.73, 3852–3856. 10.1073/pnas.73.11.3852
Summary
Keywords
non-coding RNA, circular RNA (cirRNA), long non-coding RNA(lncRNA), solid tumour, metastasis
Citation
Roy B, Dutta S and Mukherjee C (2023) Editorial: Role of non-coding RNAs in development and metastasis of solid tumours. Front. Cell Dev. Biol. 11:1281200. doi: 10.3389/fcell.2023.1281200
Received
22 August 2023
Accepted
18 September 2023
Published
25 September 2023
Volume
11 - 2023
Edited and reviewed by
Shyamala Maheswaran, Massachusetts General Hospital and Harvard Medical School, United States
Updates
Copyright
© 2023 Roy, Dutta and Mukherjee.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Chandrama Mukherjee, chandrama.dbs@presiuniv.ac.in
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.