REVIEW article
Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1520739
Periostin-integrin signaling in hepatocellular carcinoma: from biological function to clinical application
Provisionally accepted
- 1Mudanjiang Medical University, Mudanjiang, China
- 2Qiqihar Medical University, Qiqihar, Heilongjiang Province, China
- 3Jining University, Qufu, China
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Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide and the most common primary tumor. Periostin (POSTN) is located in the extracellular matrix (ECM) and triggers tumor growth signals by binding to integrin receptors. The interaction of highly expressed POSTN with cell surface receptor integrins regulates intracellular signaling pathways and promotes HCC progression. In this review, the structure and isoforms of POSTN will be summarized, and the relationship between POSTN-integrin signaling and the diagnosis and prognosis of HCC patients, tumor cell proliferation and metastasis, immune escape, cancer stem cells and angiogenesis will be reviewed. The interaction between POSTN-integrin and the key signaling pathways of HCC and its mechanism in disease progression were emphasized, and the potential value of this signaling axis as a therapeutic target for HCC was explored, providing a theoretical basis for in-depth understanding of the pathophysiological process of HCC and the development of new therapeutic strategies.
Keywords: Hepatocellular Carcinoma, periostin, integrin, Extracellular Matrix, Cancerassociated fibroblasts
Received: 31 Oct 2024; Accepted: 28 Aug 2025.
Copyright: © 2025 Teng, Liu, Yuan, Yuan and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qi Yuan, Mudanjiang Medical University, Mudanjiang, China
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