REVIEW article
Front. Cell Dev. Biol.
Sec. Cell Death and Survival
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1520850
This article is part of the Research TopicThe Role of Autophagy in Cardiovascular DiseaseView all 4 articles
Cardiovascular diseases in the elderly: possibilities to modulate autophagy using non-coding RNAs
Provisionally accepted
- Dept. of Biology, University of Padua, Padua, Non United States Or Canada, Italy
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Autophagy is a crucial mechanism implicated in both aging and cardiovascular disease, two closely interconnected conditions. Modulation of autophagy exerts a profound impact on cellular aging and the maintenance of cardiovascular function under physiological or pathological conditions. Consequently, modulation of autophagy may serve as an effective strategy to counteract age-induced vascular and cardiac remodelling and alleviate cardiovascular disease. This comprehensive review elucidates the multifaceted impact of autophagy on the aging of the cardiovascular system. It comprehensively analyses both vascular and cardiac tissues in distinct contexts, including vascular and cardiac malignancies. It also emphasizes the significance of noncoding RNAs (ncRNAs) in the epigenetic regulation of gene expression and their role as biomarkers of cardiovascular pathologies, while maintaining a clear distinction between vascular and cardiac tissues. Preclinical and clinical models were described to enhance the importance of ncRNAs in disease treatment, considering their involvement in the modulation of autophagy within the cardiocirculatory system. Finally, to underscore the paramount importance of autophagy, we conducted a comprehensive meta-analysis of transcriptomic data, demonstrating that autophagy is a process frequently dysregulated in both cardiac and vascular cells under pathological conditions. This finding enmphasizes the importance of investigating novel strategies for modulating autophagy as a potential therapeutic approach for the management of age-related cardiovascular disorders.
Keywords: cardiovascular disease, Autophagy, non-coding RNAs, Ageing, Meta-analysis
Received: 31 Oct 2024; Accepted: 09 Jun 2025.
Copyright: © 2025 Scalabrin and CAGNIN. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: STEFANO CAGNIN, Dept. of Biology, University of Padua, Padua, IT-35010, Non United States Or Canada, Italy
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