MINI REVIEW article

Front. Cell Dev. Biol.

Sec. Membrane Traffic and Organelle Dynamics

Volume 13 - 2025 | doi: 10.3389/fcell.2025.1527083

This article is part of the Research TopicReviews and Advances in the Membrane Trafficking of CancerView all 3 articles

Cellular mechanisms of hormone secretion in neuroendocrine tumors: what goes wrong?

Provisionally accepted
Laura StreitLaura Streit1Émeline TanguyÉmeline Tanguy1Laurent BrunaudLaurent Brunaud2Petra TóthPetra Tóth1Nicolas VitaleNicolas Vitale1Stéphane OryStéphane Ory1Stephane GasmanStephane Gasman1*
  • 1Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France
  • 2Département de Chirurgie Viscérale, Métabolique et Cancérologique (CVMC), INSERM NGERE-U1256, Université de Lorraine, CHRU Nancy, Hôpital Brabois adultes, Vandoeuvre-lès-Nancy, France

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Neuroendocrine tumors (NETs) constitute a heterogeneous group of neoplasms arising from hormone-releasing cells. Secretion of hormones stored in vesicles occurs through calcium-regulated exocytosis, a process that needs to be tightly controlled to avoid unbalanced levels of hormones. A critical feature shared by most of the NETs is a dysfunctional secretory pathway mainly leading to hypersecretion, which often induces clinical complications. In this review, we focus on the cellular process of hormone exocytosis and discuss the potential molecular mechanisms leading to deregulated hormone secretion in various NETs. Particular attention is paid to expression level modifications for genes and proteins involved in the exocytic pathway in NETs.

Keywords: Neuroendocrine Tumors, hormone, secretion, vesicular trafficking, Exocytosis

Received: 12 Nov 2024; Accepted: 05 Jun 2025.

Copyright: © 2025 Streit, Tanguy, Brunaud, Tóth, Vitale, Ory and Gasman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Stephane Gasman, Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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