REVIEW article
Front. Cell Dev. Biol.
Sec. Signaling
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1550859
This article is part of the Research TopicSystems Biology: Encoding Cell Signaling with Quantitative Molecular Tools and ModelsView all 4 articles
The nuclear envelope and nuclear pore complexes in neurodegenerative diseases
Provisionally accepted
- 1Institute of Neurology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China
- 2Department of Neurology, School of Medicine, University of California, Davis, Sacramento, California, United States
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The nuclear envelope (NE) and nuclear pore complexes (NPCs) play a critical role in maintaining the balance between the nucleus and cytoplasm, which is essential for the structural integrity and gene regulatory functions of eukaryotic cells. Disruptions in the nucleocytoplasmic trafficking mediated by the NE and NPCs can compromise nuclear integrity and transport homeostasis, ultimately threatening cellular viability. Recent research has highlighted a strong link between dysfunction of the NE and NPCs and the onset of neurodegenerative disorders. In this review, we summarize the current understanding of how impairments in nuclear transport contribute to the pathogenesis of neurodegenerative diseases, with a particular focus on the NE and NPCs. We aim to shed light on the intricate relationship between these molecular gatekeepers and the pathological cascade leading to neuronal degeneration, while also exploring potential strategies to restore cellular homeostasis and mitigate the progression of these devastating neurological conditions.
Keywords: Nuclear Envelope, nuclear pore complexes, nucleoporins, Neurodegenerative Diseases, nuclear transport
Received: 24 Dec 2024; Accepted: 28 Apr 2025.
Copyright: © 2025 Wu, Xu, Cheng, Guo and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xi Chen, Institute of Neurology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China
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