MINI REVIEW article
Front. Cell Dev. Biol.
Sec. Cell Death and Survival
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1559423
SLC7A11-mediated cell death mechanism in cancer: a comparative study of disulfidptosis and ferroptosis
Provisionally accepted
- Wenzhou Medical University, Wenzhou, China
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SLC7A11, also known as Sodium-Coupled Neutral Amino Acid Transporter 11, is an essential transporter protein that plays a vital role in the intracellular transport of amino acids, especially cysteine. Recently, its involvement in cell death mechanisms has attracted considerable interest, underscoring its significance in both normal physiological functions and various disease states. This paper aims to provide a thorough overview of current understanding of the role of SLC7A11 in two specific types of cell death: disulfidptosis and ferroptosis. We highlight the dual functions of SLC7A11 in these processes, examining how its activity changes under different pathological conditions and what this means for potential therapeutic approaches. In this study, we clarify the regulatory mechanisms governing SLC7A11 and its influence on cell death, ultimately presenting new insights that could guide future research in targeted therapies.
Keywords: SLC7A11, disulfidptosis, ferroptosis, Cancer, amino acid transport
Received: 12 Jan 2025; Accepted: 29 May 2025.
Copyright: © 2025 Zhu, Liu, Yu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ze Yu, Wenzhou Medical University, Wenzhou, China
Hong-Qiang Wang, Wenzhou Medical University, Wenzhou, China
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