ORIGINAL RESEARCH article
Front. Cell Dev. Biol.
Sec. Cellular Biochemistry
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1575431
This article is part of the Research TopicAdvances in Multi-Omics Technologies in Pathophysiological Processes and Disease DiagnosticsView all 5 articles
Identification of plasma lipid metabolism and potential biomarkers in patients with different coronary occlusive acute myocardial infarction
Provisionally accepted
- 1Wuxi No 2 People’s Hospital of Jiangnan University Medical Center, Wuxi, China
- 2Changzhou Children's Hospital, Changzhou, China
- 3Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Acute myocardial infarction (AMI) is the major cause of death worldwide. We aim to compare the differences in plasma lipid metabolites between AMI patients and normal controls to search for biomarker molecules for AMI with different infarct sites. 12 patients in Group A (left coronary artery occlusion), 15 patients in Group B (right coronary artery occlusion) and 14 patients in Group C (normal controls) from June 2020 to June 2021 were enrolled. Non-targeted lipidomic analysis was performed. 93 differential lipid molecules were identified. Diagnostic efficiency were evaluated by receiver operating curve. Compared with Group C, there were 9 lipid molecules with AUC>0.8 in Group A and Group B respectively. Compared with Group B, Group A had 6 lipid molecules with AUC>0.8. These lipid molecules belonged to LPC, PC, TG, and DG classes. We focused on the LPC (20:4) as a biomarker in AMI.
Keywords: Myocardial Infarction, Lipid molecules, lipidomic, Phosphatidylcholine, Lysophosphatidylcholines
Received: 12 Feb 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Chen, Zhang, Zhou, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Li Zhang, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Xing Li, Wuxi No 2 People’s Hospital of Jiangnan University Medical Center, Wuxi, China
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