REVIEW article
Front. Cell Dev. Biol.
Sec. Membrane Traffic and Organelle Dynamics
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1575571
This article is part of the Research TopicBiology of Lysosome-Related OrganellesView all 4 articles
Engine breakdown of lysosomes and related organelles and the resulting physiology
Provisionally accepted
- Leiden University Medical Center (LUMC), Leiden, Netherlands
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Late endosomes/lysosomes (LE/Lys) and lysosome related organelles (LROs) move dynamically through cells which involve many levels of regulation. To reach their destination, they need to connect to the motor proteins dynein-dynactin, kinesin or myosin for long-range bidirectional transport along microtubules and short-range movement along actin filaments. This connection depends on various factors at the microtubule, including the MAP- and tubulin-code, as well as adaptors, Rab GTPases and effector proteins marking the LE/Lys and LRO membranes. Mutations affecting this transport results in defective LE/Lys or LRO cargo delivery often resulting in skin, neurological and/or immunological diseases. How LE/Lys and LRO transport is orchestrated and how it fails in disease states, will be discussed.
Keywords: Lysosomes, lysosome-related organelles (LROs), transport, Kinesin, dynein, Microtubules, Disease
Received: 12 Feb 2025; Accepted: 29 May 2025.
Copyright: © 2025 Bakker, Jongsma and Neefjes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jacques Neefjes, Leiden University Medical Center (LUMC), Leiden, Netherlands
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