MINI REVIEW article
Front. Cell Dev. Biol.
Sec. Cell Growth and Division
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1582796
This article is part of the Research TopicAdvances in Cilia and Flagella ResearchView all 5 articles
Cilia and Transcription: A Mini Review
Provisionally accepted
- Department of Biology, Salem State University, Salem, United States
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Cilia assembly is accompanied by rapid and highly coordinated transcription of hundreds of genes. Cilia gene regulation has been studied extensively in both metazoans and unicellular model organisms. The forkhead and RFX family transcription factors regulating cilia genes in animals were first identified 25 years ago and considerable molecular details of the regulatory processes have been described since then. While many of the most important early studies of cilia gene regulation were done in unicellular organisms, additional molecular players need to be discovered for a more complete understanding in these organisms. In this concise review, written primarily for students new to the field, I present a brief history of research on cilia gene regulation, highlight some key metazoan discoveries from the last decade, and discuss gaps in our understanding of cilia gene regulation in unicellular model organisms with a focus on Chlamydomonas reinhardtii.
Keywords: Cilia, Flagella, transcription, Chlamydomonas, FoxJ1, RFX, XAP5
Received: 25 Feb 2025; Accepted: 30 May 2025.
Copyright: © 2025 Brown. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jason M Brown, Department of Biology, Salem State University, Salem, United States
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