REVIEW article
Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1589169
Progress of bone marrow mesenchymal stem cell transplantation on neural plasticity in brain
Provisionally accepted
- 1Loughborough University, Loughborough, United Kingdom
- 2Shanghai University of Sport, Shanghai, China
- 3Shanghai University, Shanghai, Shanghai Municipality, China
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Stem cells are cells with strong proliferation and differentiation abilities. Among all stem cells, bone marrow mesenchymal stem cells (BMSCs) have been extensively studied. BMSCs have the ability to self-renew and differentiate into nerve cells, and participate in cell migration and survival. These cells can also secrete neurotrophic factors through paracrine pathways to affect neural plasticity. Transplantation of BMSCs can affect neural plasticity and is the main treatment method for stroke or other traumatic brain diseases. This article elaborates on the role of BMSC transplantation in neural plasticity, neurotrophic factors, and synaptic changes, and comprehensively analyzes its potential molecular mechanisms to provide a theoretical basis for clinical treatment of brain diseases.
Keywords: BMSCs, neural plasticity, Neurogenesis, Inflammation, Oxidative Stress, Exosomes
Received: 07 Mar 2025; Accepted: 28 May 2025.
Copyright: © 2025 Li, Liu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jingjing Li, Shanghai University, Shanghai, 200444, Shanghai Municipality, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.