MINI REVIEW article
Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1589726
This article is part of the Research TopicMicrobiota Homeostasis and Metabolic Reprogramming in Cancer Development and Digestive DiseasesView all 5 articles
Microbiota Dysbiosis Impact on the Metabolism of T3 and T4 Hormones and its Association with Thyroid Cancer
Provisionally accepted
Santiago Cadena-Ullauri
Patricia Guevara-Ramírez
Elius Andrés Paz Cruz
Viviana A. Ruiz-Pozo
Rafael Tamayo-Trujillo
Ana Karina Zambrano*- Centro de Investigación Genética y Genómica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito, Ecuador, Quito, Ecuador
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This review explores the impact of gut microbiota dysbiosis on thyroid hormone metabolism and its potential association with thyroid cancer. The analysis highlights specific bacterial genera linked to thyroid dysfunction, the role of gut microbiota in iodine absorption, and mechanisms connecting dysbiosis with thyroid disorders such as hypothyroidism, hyperthyroidism, Hashimoto's thyroiditis, and Graves' disease. Additionally, it examines the potential of gut microbiota as a biomarker for diagnosis and personalized treatment, as well as the prospect of probiotics and microbiota-targeted treatments. The review emphasizes the importance of conducting additional research to fully understand microbiota-thyroid interactions and develop appropriate therapies to improve clinical outcomes and patient quality of life.
Keywords: microbiota, thyroid, healthcare, Cancer, Dysbiosis, metabolism Font: (Default) Times New Roman, English (US)
Received: 07 Mar 2025; Accepted: 22 May 2025.
Copyright: © 2025 Cadena-Ullauri, Guevara-Ramírez, Paz Cruz, Ruiz-Pozo, Tamayo-Trujillo and Zambrano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ana Karina Zambrano, Centro de Investigación Genética y Genómica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito, Ecuador, Quito, Ecuador
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