REVIEW article
Front. Cell Dev. Biol.
Sec. Molecular and Cellular Pathology
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1590009
This article is part of the Research TopicFrom Eye to Brain: Clinical and Pathological Implications of Ocular DisordersView all 3 articles
Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain
Provisionally accepted
- 1College of Special Education, Beijing Union University, Beijing, China
- 2Experimental Research Center, China Academy of Chinese Medical Science, Beijing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
As a developmental vision disorder, amblyopia has traditionally been studied with a focus on neurons. However, the neurovascular unit (NVU), a dynamic functional complex of neurons, blood vessels, and glial cells, has recently been implicated in amblyopia. This review systematically discusses the pathological changes and functional interactions of the NVU in retina and brain in amblyopia patients and experimental models, providing a new perspective for clinical intervention.
Keywords: Amblyopia, neurovascular unit, Retina, Brain, neural plasticity
Received: 08 Mar 2025; Accepted: 13 Jun 2025.
Copyright: © 2025 Zhang, Zhao, Shi, Wu and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yi Shen, College of Special Education, Beijing Union University, Beijing, 100075, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.