Biological Disturbance of MiR-425 and Its Application Prospects in Cardiovascular Diseases

Shan Zhou¹Bo Han^1,2*

• ¹Department of Pediatric Cardiology, Shandong Provincial Hospital Affiliated to Shandong first Medical University, Jinan, Shandong Province, China
• ²The Laboratory of Medical Science and Technology Innovation Center (Institute of Biomedical Engineering and Interdisciplinary Studies), Shandong First Medical University, jinan, China

MiR-425 is a biological molecule that has potential applications in cardiovascular diseases. It can regulate biological functions by combining with LncRNAs, binding with proteins, and changing the differentiation of immune cells. MiR-425 also has a role as a biomarker of disease. In cardiovascular diseases, it has clinical significance in reducing inflammation and heart repair, inducing angiogenesis, improving the prediction of atherosclerosis, reducing cardiac fibrosis, and regulating atrial natriuretic peptide to affect cardiovascular function. Target gene prediction and KEGG enrichment analysis are also mentioned. 1.Introduction MicroRNAs (miRNAs) are non-coding RNA molecules containing 21 to 23 nucleotides. These molecular entities are ubiquitously distributed across botanical, zoological, and select viral organisms. Such regulatory molecules participate critically in RNA suppression mechanisms and modulate post-transcriptional genetic expression dynamics. These abbreviated genomic modulators orchestrate precise nucleotide complementarity with specific messenger ribonucleic acid transcript fragments. The regulatory mechanisms encompass multiple strategic interventions: fragmenting targeted RNA strands into discrete molecular components, inducing transcript instability through poly(A) tail truncation, or marginally suppressing protein translation processes. Structurally, these genetic regulatory elements demonstrate remarkable similarities to small interfering ribonucleic acid molecules within RNA interference cascades. Notably, distinctive biogenesis pathways differentiate these molecular actors: the compact regulatory sequences emerge from intricate RNA transcript regions capable of forming condensed hairpin configurations, whereas their counterpart interference RNAs originate from extended double-stranded RNA molecular domains(1). Genomic computational analyses propose that the Homo sapiens genetic landscape potentially harbors approximately 1,900 to 2,300 compact regulatory ribonucleic acid sequences. Nevertheless, rigorous scholarly curation reveals a more conservative estimate, with merely 500 validated genetic elements meeting stringent molecular classification criteria within the authoritative microRNA gene repository (MirGeneDB). MiRNAs are released into body fluids including blood(2), urine(3), sweat(4), Human Breast Milk(5), Saliva(6), Tear(7) and cerebrospinal fluid(8) and have the potential to be available as biomarkers in a number of diseases.