REVIEW article
Front. Cell Dev. Biol.
Sec. Signaling
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1595362
Hippo/YAP signaling's multifaceted crosstalk in cancer
Provisionally accepted
Jie Zhang1
Haipeng Wu2Xinxin Ren3Zhuoshi Chen1Siyu Ye1Shuchang Chen1Jie Fang1*
Qirou Wu1*
Tiejun Zhao1*- 1Hangzhou City University, Hangzhou, China
- 2Zhejiang University, Hangzhou, Zhejiang Province, China
- 3Zhejiang Normal University, Jinhua, Zhejiang Province, China
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The Hippo/yes-associated protein (YAP) signaling is an evolutionarily conserved regulator in organ size control, which plays pivotal roles in cell proliferation, differentiation, apoptosis, and tissue regeneration. In cancer, dysregulation of Hippo/YAP signaling is typically recognized as one of the crucial drivers in tumorigenesis. However, beyond its canonical transcriptional targets, Hippo/YAP signaling engages in extensive crosstalk with multiple pathways to form an intricate regulatory network, thereby giving rise to its content-dependent influence on tumor initiation, progression and metastasis. This review focuses on the molecular mechanisms underlying the interplay between Hippo/YAP and pivotal signaling pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), wingless-type (Wnt)/β-catenin signaling pathway, transforming growth factor-beta (TGF-b), Hedgehog, Notch and other signaling pathways, as well as their implications in cancer biology. Ultimately, exploiting these mechanisms may represent promising therapeutic strategies for cancer.
Keywords: Hippo/Yap signaling, signaling pathway, Cross Talk, Cancer, Therapeutic target
Received: 18 Mar 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Zhang, Wu, Ren, Chen, Ye, Chen, Fang, Wu and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jie Fang, Hangzhou City University, Hangzhou, China
Qirou Wu, Hangzhou City University, Hangzhou, China
Tiejun Zhao, Hangzhou City University, Hangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.