REVIEW article
Front. Cell Dev. Biol.
Sec. Molecular and Cellular Pathology
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1596039
This article is part of the Research TopicEndothelium, Innate Immunity and Coagulation in Hematological DisordersView all 9 articles
Advances in the comprehensive mechanisms, diagnosis, and treatment of heatstroke-induced coagulopathy
Provisionally accepted
- 1People's Liberation Army General Hospital, Beijing, China
- 2Xuzhou Medical University, Xuzhou, Jiangsu Province, China
- 3Lanzhou University, Lanzhou, Gansu Province, China
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Heatstroke (HS) is a life-threatening condition that is precipitated by heat stress. The coagulation disorder that consequentially develops is termed heatstroke-induced coagulopathy (HIC). HIC typically presents as either hypocoagulopathy or hypercoagulopathy and is a principal complication that contributes to HS-associated mortality. There is no current consensus regarding HIC pathophysiology and specific pharmacological treatments. We review the diagnostic approaches, underlying mechanisms, and therapeutic interventions for HIC, with a particular emphasis on pharmacological treatments that include replacement therapy, anticoagulant therapy, traditional Chinese medicine , and novel therapies. The aim of this study is to enhance HIC awareness among clinicians and researchers and discuss the latest treatment strategy advancements to ultimately facilitate comprehensive HIC management and reduce its mortality rate.
Keywords: heatstroke, heatstroke-induced coagulopathy, diagnostic criteria, Pathogenesis, Substitute, anticoagulation
Received: 20 Mar 2025; Accepted: 27 Jun 2025.
Copyright: © 2025 Fu, Xiang, Gao, Liu, Xiang, Zhu, Zhao and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shihui Fu, People's Liberation Army General Hospital, Beijing, China
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