Biomedical Applications of Organoids Derived from the Digestive System

Xu ZhenshengZhongwen LeiCheng qiuhuaYuanhui GaoXiang yang^*

• Haikou Hospital Affiliated to Xiangya School of Medicine, Central South University, Haikou, China

As a novel cell culture technique, organoid technology has the ability to mimic the complex structure and function of human organs outside the body. In the context of the digestive system, this advanced biomedical tool is driving deeper scientific inquiry thanks to its distinctive benefits. By accurately culturing and differentiating human stem cells in vitro, this method produces organoids that exhibit high tissue specificity and functional integrity, which are essential for modeling the physiological and pathological processes of the human digestive tract. In the development of disease models, organoids can reproduce the intricate pathological characteristics of various digestive disorders, such as inflammatory bowel disease and gastrointestinal cancers, providing precise targets and efficient screening platforms for drug discovery. In terms of drug screening and toxicity evaluation, the use of organoids markedly improves the precision of safety and efficacy assessments, thereby lowering the risk of clinical trial failures and reducing dependence on animal testing. Furthermore, organoid technology plays a vital role in personalized medicine by tailoring treatments according to individual genetic profiles and disease conditions, enabling more targeted therapies. With ongoing improvements in organoid technology, its potential applications in gastrointestinal disease research are extensive. It is expected to serve as a major catalyst for advancing gastrointestinal medicine and ultimately enhancing patient health outcomes.