REVIEW article
Front. Cell Dev. Biol.
Sec. Signaling
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1603752
This article is part of the Research Topic7th International Symposium on Peripheral Nerve Regeneration: Peripheral Nerve Regeneration - Advances and New DirectionsView all 14 articles
Pharmacologically targeting Schwann cells to improve regeneration following nerve damage
Provisionally accepted
- 1UCL School of Pharmacy, University College London, London, United Kingdom
- 2Centre for Nerve Engineering, University College London, London, England, United Kingdom
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Schwann cells provide essential support for nerve growth and survival following peripheral nerve damage by producing various growth factors and other signalling molecules. Modulating the proliferation, differentiation, migration, or myelination of Schwann cells could result in accelerated repair and regeneration of injured nerves, ultimately leading to improved motor and sensory function. Therefore, Schwann cells are commonly advocated as therapeutic targets for nerve damage, which could be mediated by pharmacological intervention. This review discusses how compounds such as growth factors, hormones, and small molecules can regulate intracellular signalling pathways involved in modulating Schwann cells.
Keywords: Nerve Regeneration, Schwann Cells, Signalling pathway, Pharmacological intervention, cell phenotype
Received: 31 Mar 2025; Accepted: 28 May 2025.
Copyright: © 2025 Alhamdi, Mackie, Trueman and Rayner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Melissa LD Rayner, UCL School of Pharmacy, University College London, London, United Kingdom
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.