REVIEW article
Front. Cell Dev. Biol.
Sec. Membrane Traffic and Organelle Dynamics
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1603999
This article is part of the Research TopicBiology of Lysosome-Related OrganellesView all articles
Biogenesis and homeostasis of mast cell lysosome related secretory granules
Provisionally accepted
- Cell and Develomental Biology, Tel Aviv University, Tel Aviv, Israel
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Mast cells (MCs) are sentinel cells of the immune system that play important protective roles in innate host defenses but are also key effectors of allergic responses and chronic inflammatory diseases. Both physiological and pathophysiological responses of MCs are mediated by the release of inflammatory mediators, many of which are stored, preformed, in secretory granules (SGs), and released by regulated exocytosis in response to multiple stimuli. MC SGs belong to the family of lysosome related organelles (LROs), as indicated by their content of lysosomal hydrolases, lysosomal membrane proteins and acidic pH. The SGs derive from the Golgi and increase in size in a quantal manner by their fusion with additional SGs. They have access to external cargo, which they acquire by fusion with endosomes and contain LC3, which they acquire by fusion with amphisomes. This review discusses the underlying mechanisms of MC SG biogenesis and remodeling.
Keywords: Mast Cells, lysosome related organelles (LRO), secretory granules, amphisomes, Fusion, Fission
Received: 01 Apr 2025; Accepted: 12 May 2025.
Copyright: © 2025 Sagi-Eisenberg. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ronit Sagi-Eisenberg, Cell and Develomental Biology, Tel Aviv University, Tel Aviv, Israel
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