REVIEW article
Front. Cell Dev. Biol.
Sec. Signaling
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1604539
This article is part of the Research TopicBidirectional Gut-Brain Interactions in Modulating Central Nervous System DiseasesView all 5 articles
The Role of Gut Microbiota Dysbiosis in Drug-Induced Brain Injury: Mechanisms and Therapeutic Implications
Provisionally accepted
- 1First Affiliated Hospital of Jilin University, Changchun, China
- 2School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin Province, China
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Drug-induced brain injury (DIBI) results from toxicity, interactions or misuse and is increasingly linked to gut-microbiota dysbiosis operating via the gut-brain axis.Disturbed microbial balance drives three core mechanisms-oxidative stress, neuroinflammation and metabolic dysfunction-leading to blood-brain barrier leakage, neuronal loss and cognitive impairment; antibiotics, antineoplastics and psychoactive drugs further promote bacterial translocation and systemic inflammation.Microbial metabolites and neurotransmitters also mediate post-injury anxiety and depression. Restoring microbial equilibrium with probiotics, prebiotics or microbiota transplantation attenuates these pathways and offers a promising therapeutic strategy for DIBI.
Keywords: Drug-induced brain injury, Gut Microbiota, gut-brain axis, Neuroinflammation, Blood-Brain Barrier
Received: 02 Apr 2025; Accepted: 06 Aug 2025.
Copyright: © 2025 Zhai, Zhang, Ma, Zhang, Jin and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sixi Zhang, First Affiliated Hospital of Jilin University, Changchun, China
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