EDITORIAL article
Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1607145
This article is part of the Research TopicAdvancements in Hematopoietic Stem Cell Proliferation and Self-Renewal MaintenanceView all 7 articles
Advancements in Hematopoietic Stem Cell Proliferation and Self-Renewal Maintenance
Provisionally accepted
- 1University of California, San Francisco, San Francisco, United States
- 2Netaji Subhas University of Technology, Delhi, National Capital Territory of Delhi, India
- 3Tokyo Metropolitan Institute of Medical Science, Tokyo, Tôkyô, Japan
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with their self-renewing populations (SRPs) serving as a primary reservoir within the bone marrow [1]. These cells replenish precursor populations and support the hierarchical development of myeloid, lymphoid, and erythroid intermediates, further differentiating into short-lived immune and blood cell lineages [2]. SRPs play a vital role in immune defense, contributing to responses against infections, cancer, and radiation-induced immunosuppression [3,4]. Among SRPs, longterm culture-initiating cells (LTC-ICs) are essential in restoring hematopoietic function after radiation exposure [1,2]. These cells can regenerate depleted precursor and progenitor populations, making them invaluable for treating patients exposed to high radiation doses [5].However, despite their therapeutic potential, direct transplantation of SRPs presents significant challenges due to the difficulty in mobilizing and harvesting them in sufficient quantities for clinical application [6,7]. Traditional methods, such as direct bone marrow aspiration from the iliac crest or in vitro expansion, are invasive and have logistical constraints. Meanwhile, cytokine-driven expansion requires prohibitively high doses, making it financially and biologically unfeasible. This underscores the need for novel strategies to enhance SRP availability, including gene therapy, combination treatments with cytokines and small molecules, and innovative approaches to preserving their self-renewal capacity while maintaining stemness. This research topic combines cutting-edge methodologies and protocols that advance HSC proliferation and self-renewal. This collection fosters critical discussions on optimizing SRP expansion and sustainability by consolidating insights from established and emerging techniques.As the field progresses, continued research will be essential to unlocking the full therapeutic potential of these self-renewing hematopoietic stem cells, paving the way for advancements in
Keywords: Hematopoietic stem cells (HSCS), Self-renewing populations (SRPs), Bone marrow - pathology, Long-term culture-initiating cells (LTC-ICs), Hematopoietic stem and progenitor cells (HSPCs), induced pluripotent stem cells (iPSCs), self-renewal, proliferation
Received: 07 Apr 2025; Accepted: 04 Jun 2025.
Copyright: © 2025 Raghav, Gangenahalli and Hara. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dr. Pawan Kumar Raghav, University of California, San Francisco, San Francisco, United States
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