REVIEW article
Front. Cell Dev. Biol.
Sec. Cellular Biochemistry
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1608750
This article is part of the Research TopicMulti-omics to shed light on the pathogenesis of multifactorial diseasesView all articles
Targeting Alveolar Epithelial Cell Metabolism in Pulmonary Fibrosis: Pioneering an Emerging Therapeutic Strategy
Provisionally accepted
- Zunyi Medical University, Zunyi, Guizhou Province, China
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Pulmonary fibrosis (PF) is a chronic and progressive lung disease, characterized by excessive deposition of fibrotic connective tissue within the lungs. Advances in transcriptomics, proteomics, and metabolomics have enhanced our understanding of PF's pathogenesis. Recent studies have indicates that metabolic abnormalities in alveolar epithelial cells (AECs) play a central role in the pathogenesis of PF. Metabolic reprogramming of AECs affects cellular senescence, endoplasmic reticulum stress, and oxidative stress in AECs, while also promoting fibrotic progression through various signaling pathways. This review focuses on therapeutic strategies targeting the metabolism of AECs. It comprehensively explores the role of metabolic pathways through glucose metabolism, lipid metabolism, and amino acid metabolism in the pathogenesis of PF, aiming to provide novel theoretical support and research perspectives for preventing and treating pulmonary fibrosis.
Keywords: Pulmonary Fibrosis, metabolic reprogramming, Alveolar epithelial cells, PF, Pulmonary fibrosis, AEC, Alveolar Epithelial Cell, IPF, idiopathic pulmonary fibrosis, ILD, interstitial lung disease, FDA, food and drug administration
Received: 09 Apr 2025; Accepted: 16 May 2025.
Copyright: © 2025 Dai, Liang, Li, Zhao, Li, Li, Zhao and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Juanjuan Zhao, Zunyi Medical University, Zunyi, 563000, Guizhou Province, China
Lin Xu, Zunyi Medical University, Zunyi, 563000, Guizhou Province, China
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