REVIEW article

Front. Cell Dev. Biol.

Sec. Molecular and Cellular Pathology

Volume 13 - 2025 | doi: 10.3389/fcell.2025.1608902

This article is part of the Research TopicAdvances in Skin Barrier Dysfunction and Disease PathogenesisView all articles

miRNAs and exosomes in psoriasis: coordinating cytoskeleton dynamics and extracellular matrix remodeling

Provisionally accepted
Sijing LiSijing Li1,2*Zamri ChikZamri Chik3Farid Nazer FaruquFarid Nazer Faruqu3Najihah Mohd HashimNajihah Mohd Hashim4Nor Saadah Mohd YusofNor Saadah Mohd Yusof2Jennifer Fernandez AlarconJennifer Fernandez Alarcon5Noraini AhmadNoraini Ahmad2*
  • 1Department of Biomedical Engineering, School of Engineering, Dali University, Dali, China
  • 2Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
  • 3Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia
  • 5Grup d'Enginyeria de Materials (Gemat), Institut Químic de Sarrià (IQS), Ramon Llull University, Barcelona, Catalonia, Spain

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Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation, immune dysregulation, and abnormal epidermal differentiation. Its pathogenesis involves complex interactions among keratinocytes, fibroblasts, T cells, and myeloid cells, where dynamic cytoskeletal and extracellular matrix changes critically mediate intercellular communication. Emerging evidence highlights the pivotal roles of miRNAs and exosomes in coordinating these processes: miRNAs regulate cytoskeletal organization and extracellular matrix composition, while exosomes act as intercellular messengers that deliver miRNA-mediated signals, collectively shaping cell behavior and disease progression. This review synthesizes current knowledge on how miRNA-exosome networks drive cytoskeleton-extracellular matrix crosstalk in psoriasis, emphasizing their implications for cellular communication and tissue remodeling. By elucidating these mechanisms, we identify potential therapeutic opportunities to target pathogenic signaling pathways, offering new strategies for psoriasis management.

Keywords: Psoriasis, miRNA, Exosomes, Cytoskeleton, Extracellular Matrix

Received: 09 Apr 2025; Accepted: 24 Jun 2025.

Copyright: © 2025 Li, Chik, Faruqu, Mohd Hashim, Mohd Yusof, Fernandez Alarcon and Ahmad. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Sijing Li, Department of Biomedical Engineering, School of Engineering, Dali University, Dali, China
Noraini Ahmad, Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, 50603, Malaysia

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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