REVIEW article
Front. Cell Dev. Biol.
Sec. Membrane Traffic and Organelle Dynamics
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1613677
This article is part of the Research TopicBiology of Lysosome-Related OrganellesView all 6 articles
LRO biogenesis and function: What can we learn from mast cells?
Provisionally accepted
- Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France
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Lysosome-related organelles (LROs) are specialized compartments with cell type-specific roles. In mast cells (MCs), which are tissue-localized hematopoietic effector cells, LROs refer to secretory lysosomes also known as secretory granules (SGs) containing numerous preformed inflammatory mediators including proteases, proteoglycans, lysosomal enzymes, histamine and serotonin. Their release during MC activation is responsible for allergic, inflammatory manifestations, the fight against parasitic agents or the neutralization of toxins.Here, we provide an overview of knowledge describing the mechanisms underlying the biogenesis, secretion and biological functions of LROs in MCs. Decoding molecular mechanisms involved in LRO biogenesis and biology of MCs will benefit i) to other immune or non-immune cell types containing LROs and ii) can be exploited to design novel therapeutic approaches for the treatment of allergic and chronic inflammatory diseases caused by MC activation.
Keywords: Mast Cells, Lysosome-related organelle (LRO), secretory granules, LRO transport, LRO fusion, pre-formed inflammatory mediators
Received: 17 Apr 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Ménasché, Montero-Hernández, Zhang and Blank. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Gael Ménasché, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France
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