ORIGINAL RESEARCH article
Front. Cell Dev. Biol.
Sec. Signaling
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1619339
TRABD maintains mitochondrial homeostasis and protects against ischemia reperfusion-induced renal tubular injury
Provisionally accepted
- 1Huazhong University of Science and Technology, Wuhan, China
- 2University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China
- 3Peking University, Beijing, Beijing Municipality, China
- 4Health Science Centre, Peking University, Beijing, Beijing Municipality, China
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Mitochondria serve as hubs for many critical cellular processes, and their functions and dynamics are tightly controlled. TRABD is a Tiki/TraB family protein with unknown function. Here, we characterized TRABD as a novel outer mitochondrial membrane protein. Depletion of TRABD in cells severely impairs mitochondrial respiration and ATP production, inhibits cell growth, increases reactive oxygen species levels. Depletion of TRABD also affects mitochondrial dynamics and mitophagy, possibly through interactions with PGAM5. Knockout of TRABD in mice significantly exacerbates ischemia reperfusion-induced renal tubular injury by promoting mitochondrial fragmentation and damage. Our study identified a novel outer mitochondrial membrane protein and revealed the critical roles of TRABD in mitochondrial dynamics and ischemia reperfusion-induced renal tubular injury.
Keywords: TRABD, Mitochondrial membrane protein, dynamics, mitophagy, Ischemia Reperfusion-Induced Renal Tubular Injury
Received: 28 Apr 2025; Accepted: 02 Jul 2025.
Copyright: © 2025 Duan, Wu, Yang, Zhang, Li, Tian, Chen and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xinjun Zhang, Huazhong University of Science and Technology, Wuhan, China
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