REVIEW article

Front. Cell Dev. Biol.

Sec. Cell Growth and Division

Volume 13 - 2025 | doi: 10.3389/fcell.2025.1622107

This article is part of the Research TopicCellular Senescence in Aging-Related Diseases: Mechanisms and Therapeutic TargetsView all 5 articles

Coming of age: Could obesity-related metabolic complications be treated by targeting senescent cells?

Provisionally accepted
Barbora Judita KasperovaBarbora Judita Kasperova1,2Anna CinkajzlovaAnna Cinkajzlova1Ludek HorvathLudek Horvath1Petr SvobodaPetr Svoboda1,3Martin HaluzikMartin Haluzik1,4*Sona Stemberkova HubackovaSona Stemberkova Hubackova1,5*
  • 1Institute for Clinical and Experimental Medicine (IKEM), Prague, Czechia
  • 2First Faculty of Medicine, Charles University in Prague, Prague, Czechia
  • 3University of Chemistry and Technology, Prague, Czechia
  • 4First Faculty of Medicine, Charles University and General University Hospital, Prague, Czechia
  • 5Institute of Biotechnology, Czech Academy of Sciences, Prague-West, Czechia

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Aging is characterized by gradual deterioration of organ or tissue function and its ability to maintain homeostasis of the different physiological processes. This leads to the development of structural and functional alterations accompanied by an increased risk for diverse pathologies. Cellular senescence is a controlled biological process that could contribute to the development of many age-related diseases and related metabolic dysfunctions. Two major chronic diseases associated with premature accumulation of senescent cells that impose an enormous burden on global health systems are obesity and type 2 diabetes mellitus with its related complications.The purpose of this review is to highlight the links between aging, obesity, and type 2 diabetes mellitus, focusing on the role of cellular senescence in disease development and progression. Additionally, this review will discuss the potential of targeting cellular senescence as a promising therapeutic strategy for managing these interrelated diseases, therefore offering a novel approach to prevention and treatment.

Keywords: cellular senescence, senolytics, type 2 diabetes mellitus, Obesity, Metabolic complications

Received: 02 May 2025; Accepted: 26 May 2025.

Copyright: © 2025 Kasperova, Cinkajzlova, Horvath, Svoboda, Haluzik and Stemberkova Hubackova. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Martin Haluzik, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czechia
Sona Stemberkova Hubackova, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czechia

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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