REVIEW article
Front. Cell Dev. Biol.
Sec. Cell Death and Survival
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1622544
This article is part of the Research TopicFerroptosis, Cuproptosis, and Triaptosis: Unveiling Pathways and Translational ProspectsView all 10 articles
Ferroptosis in neurodegenerative diseases: potential mechanisms of exercise intervention
Provisionally accepted
- 1Jishou University, Jishou, China
- 2Hunan University of Medicine, Huaihua, China
- 3Hunan Mechanical & Electrical Polytechnic, Changsha, China
- 4Central South University, Changsha, China
- 5Yanshan University, Qinhuangdao, China
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Neurodegenerative diseases represent a major global cause of mortality and disability. These disorders are characterized by complex pathogenesis and currently lack effective therapeutic strategies. Iron, a vital trace element for normal brain function, has been implicated in the pathogenesis of neurodegenerative diseases via the ferroptosis pathway. Emerging evidence indicates that exercise can suppress ferroptosis directly or indirectly by regulating iron metabolism, oxidative stress, and exerkine expression, thereby conferring neuroprotection. This review summarizes current insights into the role of ferroptosis in neurodegenerative diseases and explores the mechanisms by which exercise modulates the ferroptosis pathway, offering a scientific rationale for exercise-based interventions in brain health.
Keywords: Exercise, ferroptosis, neurodegenerative disease, exerkine, iron metabolism
Received: 03 May 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Tang, Zhang, Chen, Zhou and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jianhua Zhang, Hunan University of Medicine, Huaihua, China
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