REVIEW article
Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1623959
This article is part of the Research TopicAdvancements in Stem Cell Differentiation and Disease ApplicationsView all 8 articles
The Secrets of Menstrual Blood: Emerging Frontiers from Diagnostic Tools to Stem Cell Therapies
Provisionally accepted
Yige Feng1
Yujie He2*- 1Shanxi medical university, Shanxi, Taiyuan, China
- 2First Hospital of Shanxi Medical University, Taiyuan, China
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Menstrual blood (MB), a biofluid rich in diverse cell types and biomolecules, has emerged as a vital resource for investigating female reproductive health and diseases because of its unique composition and noninvasive accessibility. This review explores the potential of MB in medical research and clinical applications, focusing on its diagnostic and therapeutic prospects.For disease diagnosis, MB offers a noninvasive sampling method for identifying biomarkers in endometriosis, cervical cancer, and other gynecological conditions. Therapeutically, stem cells derived from MB (menstrual blood-derived stem cells, MenSCs) exhibit pluripotency, high proliferative capacity, and low immunogenicity, positioning them as promising candidates in regenerative medicine. Preclinical and clinical studies have demonstrated the efficacy of MenSCs in treating infertility, premature ovarian insufficiency, intrauterine adhesions, hepatic disorders, cutaneous injuries, and neurological diseases. MenSCs also exert therapeutic effects through paracrine mechanisms by releasing cytokines and exosomes that modulate immunity, attenuate inflammation, and promote tissue repair. Despite existing challenges, MenSCs hold substantial promise for developing novel therapeutic strategies across multiple disease domains.
Keywords: Menstruation, diagnosis, therapy, Stem Cells, Research progress
Received: 06 May 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Feng and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yujie He, First Hospital of Shanxi Medical University, Taiyuan, China
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