REVIEW article
Front. Cell Dev. Biol.
Sec. Cell Adhesion and Migration
This article is part of the Research TopicMechanopathology: Unraveling the Mechanical Forces Driving Disease MechanismsView all 5 articles
The role of actin cytoskeleton component Arp2/3 in inflammatory response
Provisionally accepted
- Taiyuan Central Hospital, Taiyuan, China
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Actin regulatory protein plays an important role in immune-related diseases and affects cellular behavior by regulating the dynamic changes of the cytoskeleton. This regulation is crucial for maintaining the fine balance in the body's biological processes, and can effectively prevent and control the occurrence and development of acute or chronic inflammation, thereby avoiding the appearance of various diseases. The Arp2/3 complex, an evolutionarily conserved molecular machinery, regulates actin cytoskeleton dynamics and nucleates branched actin networks. Upon activation, the Arp2/3 complex binds to the lateral face of pre-existing actin filaments and nucleates daughter filament assembly, generating branched actin networks through this Y-junction formation mechanism. However, the research on how actin is involved in regulating the inflammatory process has only gradually become clear recently. The article mainly summarizes the functions of the actin cytoskeleton, the role of the Arp2/3 complex, and its specific functions in the inflammatory response.
Keywords: Actin Cytoskeleton, Inflammation, ARP2/3, cell migration, WASP
Received: 19 May 2025; Accepted: 03 Nov 2025.
Copyright: © 2025 Xing, Wang, Liang, Li, Yao, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jianxiao Xing, 1354863693@qq.com
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