ORIGINAL RESEARCH article
Front. Cell Dev. Biol.
Sec. Epigenomics and Epigenetics
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1643250
The value of fibroblast growth factor 21 (FGF21) promoter methylation in the repair and regeneration during the course of chronic hepatitis B
Provisionally accepted
- Qilu Hospital, Shandong University, Jinan, China
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Background: Hepatitis B virus (HBV) infection continues to pose a significant threat to global public health. The capacity for liver repair and regeneration plays a critical role in maintaining liver homeostasis during HBV infection. This study investigates the impact of FGF21 promoter methylation on liver repair and regeneration in chronic HBV infection. Methods: A total of 216 patients with chronic hepatitis B admitted to the Department of Hepatology, Qilu Hospital, Shandong University from October 2023 to October 2024, along with 15 healthy controls, were included in this study. FGF21 promoter methylation levels in peripheral blood mononuclear cells (PBMCs) were assessed using Methlight. Group comparisons were conducted using the Kruskal-Wallis Test, while Spearman correlation analysis was employed to examine the relationship between FGF21 promoter methylation levels and liver injury, repair, and regeneration in chronic HBV patients. Results: The methylation level of the FGF21 promoter in HBeAg(+) CHB patients was significantly lower compared to HBeAg(-) CHB patients and healthy controls. Additionally, HBeAg(+) CHB patients exhibited significantly higher viral loads and more severe liver damage than HBeAg(-) CHB patients. Spearman correlation analysis revealed that the methylation level of the FGF21 promoter in CHB patients was positively correlated with liver repair and regeneration capacity. Conclusion: The methylation level of FGF21 serves as an important biomarker for evaluating liver repair and regeneration ability in patients with HBV. It is closely associated with the extent of liver injury and viral load.
Keywords: FGF21, HBV, Liver Regeneration, Methylation, Oxidative Stress
Received: 08 Jun 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 Li, Zhang, Li, Zhao, Fan, Gao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shuai Gao, Qilu Hospital, Shandong University, Jinan, China
Kai Wang, Qilu Hospital, Shandong University, Jinan, China
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