REVIEW article
Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1651553
This article is part of the Research TopicMuscle Stem Cell for Skeletal Muscle RegenerationView all 3 articles
Metabolic and Molecular Regulation in Skeletal Muscle Dysfunction and Regeneration
Provisionally accepted
- 1Department of Nutritional Sciences, Oklahoma State University, Stillwater, United States
- 2School of Kinesiology, Applied Health, and Recreation, Oklahoma State University, Stillwater, United States
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Skeletal muscle is an important organ in the human body for maintaining overall strength and mobility. Skeletal muscle has the capability of self-regeneration, which can be achieved by utilizing specific energy pathways. Therefore, understanding the energy metabolism of skeletal muscle is essential to exploring its regenerative mechanisms. This review addresses the current progress in understanding the essential role of metabolic pathways in skeletal muscle function, regeneration, and muscle dysfunction as it relates to diseases such as type 2 diabetes mellitus (T2DM), obesity, and aging (sarcopenia). Furthermore, we explore the fundamental metabolisms of skeletal muscle while considering not only disease progression but also therapeutic strategies. Experimental models (in vivo and in vitro) and other signaling pathways are additionally discussed while proposing that the association between energy metabolism markers and metabolic diseases in skeletal muscle could provide innovative implications. Finally, the need for developing human-relevant models to study muscle regeneration is emphasized as most current findings are derived from in vivo and in vitro models.
Keywords: skeletal muscle, Regeneration, Metabolism, Mechanism, Metabolic Diseases
Received: 22 Jun 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Jin, Robinson, Soukup, Black, Hammer and Bae. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiyoung Bae, Department of Nutritional Sciences, Oklahoma State University, Stillwater, United States
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