ORIGINAL RESEARCH article
Front. Cell Dev. Biol.
Sec. Molecular and Cellular Pathology
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1654719
This article is part of the Research TopicArtificial Intelligence Applications in Chronic Ocular Diseases, Volume IIView all 51 articles
Refractive Error After Phacoemulsification Combined with Intraocular Lens Implantation in Primary Angle-Closure Glaucoma: A Multifactorial Analysis of Biometric Parameters and Surgical Strategies
Provisionally accepted
- Shenzhen Eye Hospital, Shenzhen, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Purpose: This study aims to explore the factors influencing refractive error following Phacoemulsification combined with intraocular lens implantation (PE+IOL) in patients with primary angle-closure glaucoma (PACG), providing a theoretical basis for preoperative consultation and IOL power selection in clinical practice.Methods: A retrospective analysis was conducted on 404 PACG patients from Shenzhen Eye Hospital between 2019 and 2024. Preoperative ocular biometric parameters and combined surgical approaches were evaluated using Spearman correlation, multinomial logistic regression, and receiver operating characteristic (ROC) curve analysis.Results: Axial length (AL), lens thickness (LT), and white-to-white distance (WTW)were key predictive factors for prediction error and postoperative refractive outcomes. AL > 22.56 mm (AUC = 0.692) and LT > 5.055 mm (AUC = 0.633) increased the risk of myopic shift (MS), while AL < 22.25 mm (AUC = 0.604) and WTW < 11.55 mm (OR = 2.209, P = 0.001) were associated with hyperopic shift (HS). The axial length/corneal radius (AL/CR) ratio > 2.986 further indicated a higher risk of MS (AUC = 0.639) postoperatively. Among patients who underwent PE+IOL combined with capsular tension ring, the proportion of HS was significantly higher (Z value = +2.95).The unique anatomical characteristics of PACG patients are key contributors to postoperative refractive instability.
Keywords: Primary angle-closure glaucoma, Cataract surgery, Refractive error, Prediction error, Postoperative refractive outcomes
Received: 26 Jun 2025; Accepted: 11 Aug 2025.
Copyright: © 2025 Liu, Gong, Dang, Deng, Deng, Junhong, Shen and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guo Junhong, Shenzhen Eye Hospital, Shenzhen, China
Xiaoli Shen, Shenzhen Eye Hospital, Shenzhen, China
Jiantao Wang, Shenzhen Eye Hospital, Shenzhen, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.