REVIEW article
Front. Cell Dev. Biol.
Sec. Membrane Traffic and Organelle Dynamics
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1656953
This article is part of the Research TopicReviews and Advances in the Membrane Trafficking of CancerView all 4 articles
A Role for Caveolin-1 in the Biology of Tumor-Derived Extracellular Vesicles New Insights and Implications
Provisionally accepted
- Membrane Mechanics and Dynamics of Intracellular Signaling Laboratory, Institut Curie, Paris, France
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Tumor-derived extracellular vesicles (TEVs) are increasingly recognized as key mediators of intercellular communication between cancer cells and their environment, a process crucial for tumor progression. TEVs can act locally on neighboring cells or travel long distances to impact remote tissues, thereby promoting tumor growth, cell invasion, pre-metastatic niche formation, and ultimately, metastasis. Despite significant insights into the molecular mechanisms by which TEVs shape the tumor microenvironment (TME) and induce pro-metastatic effects in recipient cells, many questions remain unanswered. Recent studies suggest that caveolae, invaginations of the plasma membrane with critical roles in cellular mechanics, may play an important role in TEV-mediated metastatic trait acquisition by cancer cells. The presence of caveolin-1 (Cav1) in EVs supports its involvement in EV dynamics, including biogenesis, secretion and uptake by recipient cells. Further research into the role of Cav1 in EV-mediated cancer progression could pave the way for improved diagnostic tools and novel therapeutic strategies in cancer treatment.
Keywords: Caveolae, extracellular vesicles, Cancer, mechanics, metastasis
Received: 30 Jun 2025; Accepted: 20 Aug 2025.
Copyright: © 2025 Kailasam Mani, Lamaze and Saquel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Christophe Lamaze, Membrane Mechanics and Dynamics of Intracellular Signaling Laboratory, Institut Curie, Paris, France
Cristian Saquel, Membrane Mechanics and Dynamics of Intracellular Signaling Laboratory, Institut Curie, Paris, France
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.