MINI REVIEW article
Front. Cell Dev. Biol.
Sec. Epigenomics and Epigenetics
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1657720
This article is part of the Research TopicA Year in Review: Discussions in Epigenomics and EpigeneticsView all articles
Advancing Therapeutic Target Discovery in Pulmonary Diseases: Evolution and Application of Space Exploration Technologies
Provisionally accepted
- 1Nanjing Chia Tai Tianqing Pharmaceutical Group Co Ltd, Nanjing, China
- 2Macau University of Science and Technology, Taipa, Macao, SAR China
- 3Guangzhou Medical University, Guangzhou, China
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Epigenetic alterations are associated with various pulmonary diseases. In recent years, the concept of epigenetic inheritance influenced by spatial variations has garnered increasing attention. Alterations in three-dimensional (3D) chromatin architecture have been demonstrated to play a crucial role in regulating gene expression and influencing the pathogenesis and progression of lung-related diseases. Techniques such as high-throughput chromosome conformation capture (HiC) have emerged as powerful tools for detecting spatial chromatin conformational changes. In this review, we summarize key targets identified through Hi-C and related methodologies in the context of pulmonary diseases and explore their potential implications for epigenetic therapies.
Keywords: epigenetics, Pulmonary diseases, Chromatin structure, Hi-C technology, therapeutic targets
Received: 01 Jul 2025; Accepted: 22 Aug 2025.
Copyright: © 2025 Yang, Zheng, Li, Liao, He and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhongxiao Lin, Guangzhou Medical University, Guangzhou, China
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