MINI REVIEW article
Front. Cell Dev. Biol.
Sec. Cell Death and Survival
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1662464
This article is part of the Research TopicImmunosenescence and Metabolic Reprogramming in Aging: Mechanistic Insights and InterventionsView all articles
Metabolic Reprogramming and Immunosenescence in Colorectal Cancer: Mechanisms and Therapeutic Implications
Provisionally accepted
- 1Taizhou Second People's Hospital, Taizhou, China
- 2Liyang People's Hospital, Leiyang, China
- 3Guizhou University of Traditional Chinese Medicine, Guiyang, China
- 4Suzhou Municipal Hospital, Suzhou, China
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Colorectal cancer (CRC), as a highly prevalent malignant tumor worldwide, has a persistently high incidence and mortality rate. In recent years, metabolic reprogramming and immunosenescence have received extensive attention as key mechanisms for tumorigenesis, development and treatment resistance. Metabolic reprogramming not only provides energy and biosynthetic precursors for tumor cells, but also regulates immune responses by reconstructing the tumor microenvironment (TME). Immunosenescence is characterized by the depletion of effector immune cell function and the increase in the proportion of immunosuppressive cells. The two jointly promote the immune escape and therapeutic resistance of CRC. This article systematically reviews the research progress of metabolic reprogramming and immunosenescence in colorectal cancer and explores the related targeted therapeutic strategies, aiming to provide a new theoretical perspective for the precise treatment of CRC.
Keywords: colorectal cancer, immunosenescence, metabolic reprogramming, Tumor Microenvironment, Immunotherapy
Received: 09 Jul 2025; Accepted: 31 Jul 2025.
Copyright: © 2025 Zhu, Shen, Su, Yao and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaochen Chen, Suzhou Municipal Hospital, Suzhou, China
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