REVIEW article
Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1663973
Exosomes in Arteriovenous Fistula Stenosis
Provisionally accepted
- 1Beihang University, Beijing, China
- 2Beihang University School of Biological Science and Medical Engineering, Beijing, China
- 3Sun Yat-Sen University, Guangzhou, China
- 4Jilin Cancer Hospital, Changchun, China
- 5Qianwei Hospital of Jilin Province, Changchun, China
- 6The Second Hospital of Jilin University Department of Cardiovascular, Changchun, China
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Arteriovenous fistula (AVF) stenosis is a complex pathological process caused by venous intimal hyperplasia, and its development is influenced by factors such as surgical injury, hemodynamic changes, inflammatory responses, and cellular proliferation and migration. Exosomes are critical mediators of intercellular communication and carry biomolecules (e.g., deoxyribonucleic acid, ribonucleic acid [RNA], and proteins) that can regulate cell functions and impact inflammatory responses, endothelial cell proliferation, and vascular smooth muscle cell migration. Studies have shown that molecules such as microRNAs within exosomes play significant roles in vascular stenosis-related diseases and can function as potential therapeutic tools and biomarkers for disease diagnosis. In addition, exosomes can serve as drug carriers with good biocompatibility and targeting capabilities, providing new avenues for the diagnosis and treatment of AVF stenosis. This article reviews the application of exosomes in AVF stenosis.
Keywords: Exosomes, Arteriovenous fistula (AVF), extracellular vesicles, Intimal hyperplasia, Endothelial-to-mesenchymal transition (EndoMT), vascular remodeling, Chronic kidney disease (CKD)
Received: 11 Jul 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 Cao, Guo, Chen, Li, Jie and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Weitie Wang, The Second Hospital of Jilin University Department of Cardiovascular, Changchun, China
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