MINI REVIEW article
Front. Cell Dev. Biol.
Sec. Stem Cell Research
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1672074
The Next Frontier in Lung Development and Regeneration Research: Harnessing iPSC Models to Illuminate Notch Signaling Pathways
Provisionally accepted
- 1University of Toronto, Toronto, Canada
- 2Hospital for Sick Children, University of Toronto, Toronto, Canada
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The respiratory system relies on a diverse repertoire of epithelial cell types to ensure efficient air conduction and gas exchange. This cellular heterogeneity arises through tightly coordinated intercellular signaling events that extend from embryonic development into the postnatal period. Among the key regulatory pathways, Notch signaling plays an integral role in guiding cell fate determination, proliferation, and differentiation. It is indispensable for the proper formation, maintenance, and repair of the airway epithelium. This review examines the broad influence of Notch signaling on mammalian airway epithelial biology and highlights unresolved questions—particularly those specific to human lung development—where human induced pluripotent stem cell–derived models offer promising tools to bridge existing knowledge gaps.
Keywords: Notch signaling, lung development, airway epithelial cells, Lung differentiation, Induced Pluripotent Stem Cells, Regeneration and repair
Received: 23 Jul 2025; Accepted: 27 Aug 2025.
Copyright: © 2025 Song, Yang, Lam, Quach, Yang, Salih and Wong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Amy P Wong, Hospital for Sick Children, University of Toronto, Toronto, Canada
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