REVIEW article
Front. Cell Dev. Biol.
Sec. Molecular and Cellular Pathology
The role of ADAR1 in human pathophysiology
Provisionally accepted
- 1School of Pharmacy, Southwest Medical University, Luzhou, China
- 2Department of pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, China
- 3Southwest Medical University, Luzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Adenosine deaminase 1 (ADAR1) is an enzyme acting on double-stranded RNA, primarily responsible for catalyzing the adenosine-inosine deamination reaction of dsRNA.An increasing number of studies have demonstrated that ADAR1 plays a pivotal role in various diseases, including cardiovascular, neurological, and immune disorders, among others. Some of these diseases remain incurable. In addition, ADAR1 is also involved in the development and differentiation of various crucial cells, such as hematopoietic stem cells and nerve cells.This article comprehensively summarizes the regulatory effects of ADAR1 on crucial cells and organs across the immune, nervous, respiratory, blood, and digestive systems, along with its influence on disease progression. The aim is to offer assistance in intervening in cells and treating diseases.
Keywords: ADAR1, human diseases, Physiological process, Immunity, Cancer
Received: 14 Aug 2025; Accepted: 28 Nov 2025.
Copyright: © 2025 li, xiao, Li and Dai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yan Dai
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.