MINI REVIEW article
Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1677201
Molecular Mechanisms Governing the Differentiation and Expansion of Myeloid-Derived Suppressor Cells
Provisionally accepted
- 1North Henan Medical University, Xinxiang, China
- 2Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
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Myeloid-derived suppressor cells (MDSCs) play critical roles in tumor immune evasion. These heterogeneous cells are broadly classified into granulocytic (G-MDSC), monocytic (M-MDSC), and their immature precursors, early-stage MDSCs (e-MDSCs). Elucidating their differentiation and expansion mechanisms is crucial for advancing cancer immunotherapy. This review examines the key signaling pathways (e.g., JAK/STAT, NF-κB, Notch), regulatory cytokines, metabolic factors, and epigenetic modifications central to MDSC biology. A comprehensive understanding of these 2 intricate networks provides valuable insights into tumor immune evasion and facilitates the identification of novel therapeutic targets designed to overcome MDSC-mediated immunosuppression.
Keywords: myeloid-derived suppressor cells, differentiation, expansion, Tumor Microenvironment, Signal Transduction, Immunotherapy
Received: 31 Jul 2025; Accepted: 07 Oct 2025.
Copyright: © 2025 WANG, Wang and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: KE WANG, 15537387099@163.com
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