EDITORIAL article
Front. Cell Dev. Biol.
Sec. Cellular Biochemistry
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1679902
This article is part of the Research TopicProgress in the Application of Biomaterials and Nanotechnology in Cell BiologyView all 6 articles
Editorial: Converging Frontiers in Bio/nanotechnology for Cellular Biology
Provisionally accepted
- University of Macau, Taipa, China
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The integration of biomaterials and nanotechnology is revolutionizing cell biology, as exemplified by the pioneering studies in this Research Topic.Exosome-mediated co-delivery of curcumin and methylene blue 1 demonstrates synergistic neuroprotection in Alzheimer's models, leveraging exosomes' blood-brain barrier permeability to modulate autophagy and reduce amyloid-β toxicity.Simultaneously, mechanobiology insights emerge from adipose regeneration research 2 , where dynamic force transduction activates YAP/β-catenin signaling, guiding scaffold design for transplanted adipocyte survival. Complementing therapeutic innovation, fluorescent carbon dots (CDs) within PEC-GS/BG hybrids 3 achieve real-time cellular tracking with minimal cytotoxicity, exemplifying how nanoscale optical probes illuminate intracellular dynamics. Theranostic convergence is further evident in miRNA-nanomedicine systems 4 , where tumor-targeted nanoparticles exploit endogenous regulatory pathways for combinatorial gene/chemotherapy, while precision nanomedicine advances 5 highlight biomarker-responsive nanomaterials enabling patient-specific cancer diagnosis and treatment.Collectively, these studies underscore certain transformative trends, including multifunctionality in nanocarriers, bidirectional material-cell communication, and closed-loop diagnostic-therapeutic integration. Future progress hinges on decoding nano-bio interfaces at single-cell resolution and establishing scalable biomaterial manufacturing 6 . As spatial omics and AI-driven design mature, next-generation platforms will likely transcend traditional compartmentalization, enabling real-time adaptation to cellular microenvironments 7 . This Topic crystallizes a pivotal shift toward predictive and participatory nanomedicine-where materials actively collaborate with biological systems to restore function. 1. Yang D, Deng Z, Zhou H, Zhang Q, Zhang X and Gong J (2025) Exosome-mediated dual drug delivery of curcumin and methylene blue for enhanced cognitive function and mechanistic elucidation in Alzheimer's disease therapy. Front. Cell Dev. Biol. 13:1562565. doi: 10.3389/fcell.2025.1562565 2. Ye Y, Ma J, Guo B-y, Li X-j, Hu K-k, Tan M-j and Zhang L (2024) Mechanical force promotes tissue and molecular changes in adipose tissue regeneration post-transplantation. Front. Cell Dev. Biol. 12:1472575. doi: 10.3389/fcell.2024.1472575 3. Zhang X, Gong J, Zhou H, Yin X, Wu G, Wang Q, Lin W, Wang H, Ji W and Zhang Z (2025) Fluorescent carbon dots in PEC-GS/BG hybrids and their application for bioimaging. Front. Mol. Biosci. 12:1555995. doi: 10.3389/fmolb.2025.1555995 4. Telkoparan-Akillilar P, Chichiarelli S, Tucci P and Saso L ( 2025
Keywords: Nanotechology, Biomaterials, Regenerative Medicine, Drug Delievery, Nanomaterials (A)
Received: 05 Aug 2025; Accepted: 05 Aug 2025.
Copyright: © 2025 Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Liqiang Zhou, University of Macau, Taipa, China
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