ORIGINAL RESEARCH article
Front. Cell Dev. Biol.
Sec. Embryonic Development
This article is part of the Research TopicEarly Embryonic Development: Zygotic Genome Activation and Epigenome ReprogrammingView all articles
Long-chain fatty acid β-oxidation regulates embryonic development by H3K18 acetylation in mice
Provisionally accepted
- 1Wenzhou Medical University, Wenzhou, China
- 2Ningbo Medical Centre Lihuili Hospital, Ningbo, China
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Fatty acids are not only important as energy sources, but also playing crucial roles in maintaining cellular homeostasis. However, their role in preimplantation development remains unclear. Here, we find that fatty acids gradually accumulate after 4-cell stage in mouse preimplantation development. And, the expressions of fatty acid degradation-related genes are increased along the developmental process. Inhibition of long-chain fatty acid β-oxidation (LCFAO) results in preimplantation developmental arrest, downregulated expressions of S phase-related genes, and loss of H3K18ac modification. By profiling the landscape of H3K18ac, we show that H3K18ac is enriched on the promoter regions of S phase-related genes and correlates with their expression. Together, these findings suggest that LCFAO regulate mouse preimplantation development through H3K18ac, providing additional evidence for metabolic-epigenetic crosstalk in embryonic development.
Keywords: Fatty, acid, β-oxidation, H3K18Ac, Preimplantation, development, Metabolic-Epigenetic Crosstalk, cell cycle arrest
Received: 10 Aug 2025; Accepted: 20 Nov 2025.
Copyright: © 2025 Zheng, Cui, Song, Kong, Zhang, Li and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qingran Kong, kqr721726@163.com
Jiaming Zhang, jmzhang1225@163.com
Hao Li, haoli.pub@outlook.com
Qi Zhao, zq920@163.com
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