REVIEW article
Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1694257
Extracellular Vesicle-Derived microRNAs in Renal Cell Carcinoma: Biological Roles and Clinical Applications
Provisionally accepted
Jiahui He1,2
Lanfeng Wang3
Bingqing Yu1,2
Wengbin Huang1,4Chen Ouyang4
Mingcan Zhou1,2Rong Hu1,2,4Zhiping Chen1,2,4*- 1Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
- 2College of Medical Technology, Gannan Medical University, Ganzhou, Jiangxi Province, China
- 3Department of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
- 4First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi Province, China
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Renal cell carcinoma (RCC) is a common malignant tumour of the urinary system, characterised by high heterogeneity and a tendency to metastasise, with poor prognosis in advanced patients. Although surgical resection and targeted therapies such as tyrosine kinase inhibitors and immune checkpoint inhibitors have significantly improved survival outcomes in some patients, drug resistance and recurrence remain clinical challenges.In recent years, extracellular vesicles (EVs) and the microRNAs (miRNAs) they carry have emerged as a research hotspot due to their critical roles in tumour initiation, progression, immune regulation, and drug resistance. This systematic review summarises the biological functions of EVs-derived miRNAs in renal cell carcinoma and their potential applications in clinical diagnosis and treatment, with a focus on their value in diagnosis, prognosis, immune regulation, and prediction of treatment response.
Keywords: extracellular vesicles, miRNAs, Renal cell carcinoma, Kidney cancer, biomarker
Received: 28 Aug 2025; Accepted: 08 Oct 2025.
Copyright: © 2025 He, Wang, Yu, Huang, Ouyang, Zhou, Hu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhiping Chen, hy103628@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.