REVIEW article
Front. Cell Dev. Biol.
Sec. Signaling
This article is part of the Research TopicExtracellular Vesicles Signaling in Embryogenesis and MorphogenesisView all 4 articles
Extracellular vesicles in reproductive medicine:from "animal-led" to "plant-enabled"
Provisionally accepted
- 1First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China
- 2Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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Extracellular vesicles (EVs) have emerged as pivotal mediators of intercellular communication in reproductive medicine, demonstrating considerable potential for both understanding and treating reproductive disorders. By precisely regulating key processes such as follicular development, embryo implantation, and the immune microenvironment, EVs present innovative opportunities for the precision treatment of infertility. However, the clinical translation of conventional animal-derived EVs faces significant challenges, including inherent heterogeneity, difficulties in scalable production, and ethical concerns. These limitations have accelerated the exploration of sustainable and safer alternatives, notably plant-derived extracellular vesicles (PDEVs). This paradigm shift from animal to plant sources is paving the way for a new era of green precision medicine in EV-based therapies.
Keywords: extracellular vesicles, plant-derived extracellular vesicles, Reproductive diseases, Assisted reproduction, Gametogenesis, Embryonic Development
Received: 04 Oct 2025; Accepted: 10 Nov 2025.
Copyright: © 2025 Pan, Ju, Wang, Zhang, Wang, Jiang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shuai Zhao, xiao-xue0531@163.com
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