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CORRECTION article

Front. Cell Dev. Biol., 24 November 2025

Sec. Cancer Cell Biology

Volume 13 - 2025 | https://doi.org/10.3389/fcell.2025.1728870

Correction: Tumor organoids may be more suitable for clinical personalized chemotherapeutic drug screening in lung adenocarcinoma

    WY

    Wuyang Yun 1

    YL

    Yuyu Li 2

    YG

    Yanlei Ge 3

    XZ

    Xiaoyun Zhang 1

    HL

    Huifeng Liu 4*

    WC

    Wen Chen 2*

    LX

    Li Xiao 5*

  • 1. Hebei North University, Zhangjiakou, China

  • 2. Department of Pathology, The 8th Medical Center of PLA General Hospital, Beijing, China

  • 3. North China University of Science and Technology Affiliated Hospital, Tangshan, China

  • 4. Department of Respiratory and Critical Care Medicine, The 8th Medical Center of PLA General Hospital, Beijing, China

  • 5. College of Pulmonary and Critical Care Medicine, Beijing Key Laboratory of Organ Transplantation and Immunology Regulatory, The 8th Medical Centre of Chinese PLA General Hospital, Beijing, China

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There was a mistake in Figure 1C as published.

FIGURE 1

Panel A shows cell cultures over three days, with visible growth and structural changes. Panel B presents three histological models: Organoid, Animal, and Adherent, each stained with Hematoxylin and Eosin (HE) and marked for Cytokeratin (CK). Panel C is a diagram illustrating the timeline from initial cell model to Adherent Model (two to three days), Organoid Model (seven to nine days), and Animal Model (two to three weeks).

The Organoid Model Demonstrates Advantages in Simulating 3D Spatial Structure and Morpho Function. (A) Phase-contrast microscopy images show that the organoid diameter increased with culture time, reaching 100–200 µm by day 7 (20×, scale bar: 100 µm). (B) Representative HE and immunohistochemical CK7 staining for the organoid model, animal model, and adherent model. The organoid model preserved the adenomatous structure of lung adenocarcinoma and exhibited strong CK7 expression (20×, scale bar: 100 µm). (C) Growth cycles of models based on the A549 cell line. The organoid model completed functional construction within 9 days.

In Figure 1C the culture time for the adherent model was incorrectly stated as 2–3 weeks. The correct cultivation time for the adhesive model should be 2–3 days. The corrected Figure 1 appears below.

The original article has been updated.

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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Summary

Keywords

lung cancer, organoid model, chemotherapy response, resistance evolution, Clinical Prediction, precision oncology

Citation

Yun W, Li Y, Ge Y, Zhang X, Liu H, Chen W and Xiao L (2025) Correction: Tumor organoids may be more suitable for clinical personalized chemotherapeutic drug screening in lung adenocarcinoma. Front. Cell Dev. Biol. 13:1728870. doi: 10.3389/fcell.2025.1728870

Received

21 October 2025

Revised

20 October 2025

Accepted

14 November 2025

Published

24 November 2025

Volume

13 - 2025

Edited and reviewed by

Yahima Frión-Herrera, University of Padua, Italy

Updates

Copyright

*Correspondence: Huifeng Liu, ; Wen Chen, ; Li Xiao,

†These authors have contributed equally to this work

Disclaimer

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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