REVIEW article
Front. Cell Dev. Biol.
Sec. Signaling
This article is part of the Research TopicSignaling Mechanisms in Neuro-Immune CrosstalkView all articles
Epigenetic Crosstalk in Neuroblastoma Development and Progression
Provisionally accepted
- Baylor College of Medicine, Houston, United States
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Neuroblastoma (NB), a pediatric malignancy of the peripheral nervous system, accounts for 15% of pediatric cancer deaths and remains a major challenge for cancer therapy. NB originates from sympathoadrenal (SA) progenitors of the neural crest (NC) cell lineage, whose formation and differentiation are controlled by epigenetic mechanisms. Although signaling pathways and epigenetic factors implicated in NB tumorigenesis have been well-described, a holistic understanding of how development and epigenetics overlap to drive NB is lacking. By exploring vital interplays and co-dependencies between key pathways and their epigenetic control in NC development, we have gained novel insights into the mechanisms governing NB differentiation and oncogenesis. These converging insights have enabled the application of targeted therapies against epigenetic regulators driving NB with promising implications for patient outcomes.
Keywords: epigenetics, Neural Crest, Neuroblastoma, oncogenesis, Tumor Microenvironment
Received: 16 Dec 2025; Accepted: 06 Feb 2026.
Copyright: © 2026 Drolet, Wolf, Yi and Barbieri. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Eveline Barbieri
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